Financiado en parte por Nippon Suisan Kaisya, Ltd.
Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial
Tsuchiya Y, Yanagimoto K, Nakazato K, Hayamizu K, Ochi E
European journal of applied physiology · 63 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nippon Suisan Kaisya, Ltd.
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-04-16 · Eur J Appl Physiol · vol. 116 · número 6 · págs. 1179–1188
- Editorial
- Springer Science+Business Media
- Citado
- 92 citas · más que el 97% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Exercise and Physiological Responses · Fatty Acid Research and Health · Tendon Structure and Treatment
- Palabras clave
- Docosahexaenoic acid, Fish oil, Eicosapentaenoic acid, Range of motion, Randomized controlled trial, Medicine, Placebo, Eccentric, Double blind, Physical therapy, Sports medicine, Fish <Actinopterygii>, Anesthesia, Internal medicine, Physical medicine and rehabilitation, Polyunsaturated fatty acid, Chemistry, Biology, Biochemistry, Fishery, Physics, Pathology, Fatty acid
- MeSH
- humans, muscle weakness, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fish oils, drug combinations, range of motion, articular, treatment outcome, double-blind method, placebo effect, dietary supplements, adult, male, muscle strength, resistance training, myalgia
5 autores
- Yosuke Tsuchiya🇯🇵Meiji Gakuin University
- Kenichi Yanagimoto🇯🇵Nippon Suisan Kaisha (Japan)
- Koichi Nakazato🇯🇵Nippon Sport Science University
- Kohsuke Hayamizu🇯🇵Yokohama University of Pharmacy
- Eisuke Ochi🇯🇵 · autor de correspondenciaHosei University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
This study investigated the effect of eicosapentaenoic and docosahexaenoic acids-rich fish oil (EPA + DHA) supplementation on eccentric contraction-induced muscle damage.
Methods
Twenty-four healthy men were randomly assigned to consume the EPA + DHA supplement (EPA, n = 12) or placebo (PL, n = 12) by the double-blind method. Participants consumed EPA + DHA or placebo supplement for 8 weeks prior to exercise and continued it until 5 days after exercise. The EPA group consumed EPA + DHA-rich fish oil containing 600 mg EPA and 260 mg DHA per day. Subjects performed five sets of six maximal eccentric elbow flexion exercises. Changes in the maximal voluntary contraction (MVC) torque, range of motion (ROM), upper arm circumference, muscle soreness as well as serum creatine kinase, myoglobin, IL-6, and TNF-α levels in blood were assessed before, immediately after, and 1, 2, 3, and 5 days after exercise.
Results
MVC was significantly higher in the EPA group than in the PL group at 2-5 days after exercise (p < 0.05). ROM was also significantly greater in the EPA group than in the PL group at 1-5 days after exercise (p < 0.05). At only 3 days after exercise, muscle soreness of the brachialis was significantly greater in the PL group than in the EPA group (p < 0.05), with a concomitant increase in serum IL-6 levels in the PL group.
Conclusion
Eight-week EPA + DHA supplementation attenuates strength loss and limited ROM after exercise. The supplementation also attenuates muscle soreness and elevates cytokine level, but the effect is limited.
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