Effect of Photobiomodulation on Transforming Growth Factor-β1, Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
Keskiner I, Lutfioğlu M, Aydogdu A, Saygun NI, Serdar MA
Photomedicine and laser surgery · 33 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Ondokuz Mayis Üniversitesi
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-04-18 · Photomed Laser Surg · vol. 34 · número 6 · págs. 263–271
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 50 citas · más que el 88% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Periodontal Regeneration and Treatments · Wound Healing and Treatments
- Palabras clave
- low-level laser therapy, free gingival graft, palatal wound healing, TGF-β1, PDGF-BB, interleukin-8, Nd:YAG laser
- MeSH
- palate, gingiva, humans, proto-oncogene proteins c-sis, interleukin-8, treatment outcome, double-blind method, wound healing, adolescent, adult, female, male, transforming growth factor beta1, lasers, solid-state, becaplermin
5 autores
- İlker Keskiner🇹🇷 · autor de correspondenciaOndokuz Mayıs University
- Müge Lütfioğlu🇹🇷Ondokuz Mayıs University
- Ahmet Aydoğdu🇹🇷Başkent University
- N Saygun🇹🇷Gülhane Askerî Tıp Akademisi
- Muhittin Abdulkadir Serdar🇹🇷Acıbadem University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β1, platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF).
Material and methods
Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-β1, PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA).
Results
PWF TGF-β1, PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-β1, PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-β1 levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant.
Conclusions
Observed increases in PWF TGF-β1, PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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