Pharmacokinetic analysis and comparison of caffeine administered rapidly or slowly in coffee chilled or hot versus chilled energy drink in healthy young adults
White JR, Padowski JM, Zhong Y, Chen G, Luo S, Lazarus P, Layton ME, McPherson S
Clinical toxicology (Philadelphia, Pa.) · 72 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Environmental Health Sciences (R01-ES025460)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-04-20 · Clin Toxicol (Phila) · vol. 54 · número 4 · págs. 308–312
- Editorial
- Taylor & Francis
- Citado
- 117 citas · más que el 99% de estudios similares · 10.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 12 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Coffee research and impacts · Tea Polyphenols and Effects · Pharmacology and Obesity Treatment
- Palabras clave
- Caffeine, Pharmacokinetics, Crossover study, Cmax, Context (archaeology), Analysis of variance, Chemistry, Medicine, Pharmacology, Internal medicine, Biology, Placebo
- MeSH
- humans, caffeine, cross-over studies, temperature, coffee, adolescent, adult, female, male, young adult, energy drinks
8 autores
- John Raymond White🇺🇸 · autor de correspondenciaWashington State University Spokane
- Jeannie M. Padowski🇺🇸Washington State University Spokane
- Yili Zhong🇺🇸Washington State University Spokane
- Gang Chen🇺🇸Washington State University Spokane
- Shaman Luo🇺🇸Washington State University Spokane
- Philip J. Lazarus🇺🇸Washington State University Spokane
- Matthew E. Layton🇺🇸Washington State University Spokane
- Sterling Marshall McPherson🇺🇸Providence Regional Medical Center Everett; Washington State University Spokane; Providence Health & Services
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
There is a paucity of data describing the impact of type of beverage (coffee versus energy drink), different rates of consumption and different temperature of beverages on the pharmacokinetic disposition of caffeine. Additionally, there is concern that inordinately high levels of caffeine may result from the rapid consumption of cold energy drinks.
Objective
The objective of this study was to compare the pharmacokinetics of caffeine under various drink temperature, rate of consumption and vehicle (coffee versus energy drink) conditions.
Materials
Five caffeine (dose = 160 mg) conditions were evaluated in an open-label, group-randomized, crossover fashion. After the administration of each caffeine dose, 10 serial plasma samples were harvested. Caffeine concentration was measured via liquid chromatography-mass spectrometry (LC-MS), and those concentrations were assessed by non-compartmental pharmacokinetic analysis. The calculated mean pharmacokinetic parameters were analyzed statistically by one-way repeated measures analysis of variance (RM ANOVA). If differences were found, each group was compared to the other by all pair-wise multiple comparison.
Results
Twenty-four healthy subjects ranging in age from 18 to 30 completed the study. The mean caffeine concentration time profiles were similar with overlapping SDs at all measured time points. The ANOVA revealed significant differences in mean Cmax and Vd ss/F, but no pair-wise comparisons reached statistical significance. No other differences in pharmacokinetic parameters were found.
Discussion
The results of this study are consistent with previous caffeine pharmacokinetic studies and suggest that while rate of consumption, temperature of beverage and vehicle (coffee versus energy drink) may be associated with slightly different pharmacokinetic parameters, the overall impact of these variables is small.
Conclusion
This study suggests that caffeine absorption and exposure from coffee and energy drink is similar irrespective of beverage temperature or rate of consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.