Effect of cholecalciferol supplementation on arterial stiffness: a systematic review and meta-analysis
Upala S, Sanguankeo A, Congrete S, Jaruvongvanich V
Scandinavian cardiovascular journal : SCJ · 22 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-04-22 · Scand Cardiovasc J · vol. 50 · número 4 · págs. 230–235
- Editorial
- Taylor & Francis
- Citado
- 28 citas · más que el 78% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Cardiovascular Health and Disease Prevention · Vitamin D Research Studies · Sodium Intake and Health
- Palabras clave
- Medicine, Arterial stiffness, Cholecalciferol, Vitamin D and neurology, Pulse wave velocity, Placebo, Meta-analysis, Internal medicine, Randomized controlled trial, vitamin D deficiency, Surgery, Blood pressure, Pathology
- MeSH
- humans, cardiovascular diseases, cholecalciferol, vitamins, treatment outcome, vascular stiffness, pulse wave analysis
4 autores
- Sikarin Upala🇹🇭🇺🇸Siriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
- Anawin Sanguankeo🇹🇭🇺🇸 · autor de correspondenciaSiriraj Hospital; Mahidol University; Bassett Medical Center; Columbia University
- Soontharee Congrete🇺🇸St. Elizabeth's Medical Center
- Veeravich Jaruvongvanich🇺🇸University of Hawaii System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D deficiency increases risk of cardiovascular diseases, arterial stiffness, and endothelial dysfunction. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the impact of vitamin D supplementation on arterial stiffness.
Methods
A comprehensive search of the databases of the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE was performed from inception through November 2015. The inclusion criterion was RCTs that assessed the impact of cholecalciferol supplementation in adults on the surrogate markers of arterial stiffness (aortic pulse wave velocity (PWV) and augmentation index (AIx)). Outcome was the pooled mean difference (MD) of PWV and AIx between the vitamin D supplementation (intervention) group and placebo.
Results
The initial search yielded 1164 articles. Twenty-eight articles underwent full-length review and data were extracted from seven RCTs involving totally 547 participants. Dose of cholecalciferol supplementation varied from 1000 IU/day to 120,000 IU/month of cholecalciferol. Duration of treatment ranged from 2 to 12 months. There was no significant difference in the change of PWV (pooled MD = 0.18, 95% CI: -0.17 to 0.52 or AIx (pooled MD = 2.39, 95% CI: -4.43 to 4.92) between the intervention group and placebo.
Conclusions
There was no improvement of markers of arterial stiffness after vitamin D supplementation.
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