Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression
Hallahan B, Ryan T, Hibbeln JR, Murray IT, Glynn S, Ramsden CE, SanGiovanni JP, Davis JM
The British journal of psychiatry : the journal of mental science · 136 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (Z01 AA000115)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-04-22 · Br J Psychiatry · vol. 209 · número 3 · págs. 192–201
- Editorial
- Cambridge University Press
- Citado
- 189 citas · más que el 100% de estudios similares · 18.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 86 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Tryptophan and brain disorders · Treatment of Major Depression
- Palabras clave
- Docosahexaenoic acid, Depression (economics), Placebo, Eicosapentaenoic acid, Internal medicine, Randomized controlled trial, Clinical trial, Meta-analysis, Medicine, Psychiatry, Psychology, Fatty acid, Polyunsaturated fatty acid, Alternative medicine, Biology
- MeSH
- humans, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, major depressive disorder
8 autores
- Brian P. Hallahan🇮🇪🇺🇸 · autor de correspondenciaOllscoil na Gaillimhe – University of Galway; University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- Timothy J. Ryan🇺🇸University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- Joseph R. Hibbeln🇺🇸National Institutes of Health; University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- Ivan T. Murray🇮🇪🇺🇸University Hospital Galway; University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- Shauna Glynn🇺🇸University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- Christopher E. Ramsden🇺🇸National Institutes of Health; University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- John Paul SanGiovanni🇺🇸National Institutes of Health; University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
- John M. Davis🇺🇸University of Illinois Chicago; National Institute on Alcohol Abuse and Alcoholism
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Trials evaluating efficacy of omega-3 highly unsaturated fatty acids (HUFAs) in major depressive disorder report discrepant findings.
Aims
To establish the reasons underlying inconsistent findings among randomised controlled trials (RCTs) of omega-3 HUFAs for depression and to assess implications for further trials.
Method
A systematic bibliographic search of double-blind RCTs was conducted between January 1980 and July 2014 and an exploratory hypothesis-testing meta-analysis performed in 35 RCTs including 6665 participants receiving omega-3 HUFAs and 4373 participants receiving placebo.
Results
Among participants with diagnosed depression, eicosapentaenoic acid (EPA)-predominant formulations (>50% EPA) demonstrated clinical benefits compared with placebo (Hedge's G = 0.61, P50% DHA) did not. EPA failed to prevent depressive symptoms among populations not diagnosed for depression.
Conclusions
Further RCTs should be conducted on study populations with diagnosed or clinically significant depression of adequate duration using EPA-predominant omega-3 HUFA formulations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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