A Randomized Controlled Trial of the Effect of Broccoli Sprouts on Antioxidant Gene Expression and Airway Inflammation in Asthmatics
Sudini K, Diette GB, Breysse PN, McCormack MC, Bull D, Biswal S, Zhai S, Brereton N, Peng RD, Matsui EC
The journal of allergy and clinical immunology. In practice · 43 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Gobierno
- NIAID NIH HHS
- Gobierno
- NIMHD NIH HHS
- Subvenciones
- National Cancer Institute (P30 CA 023074); National Institute of Environmental Health Sciences (P50 ES018176); National Institute of Environmental Health Sciences (P50ES015903); National Institute on Minority Health and Health Disparities (P50MD010431); National Institute of Environmental Health Sciences (R01ES023447); National Institute of Allergy and Infectious Diseases (K24AI114769); National Institute of Environmental Health Sciences (P01 ES018176)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2016-04-29 · J Allergy Clin Immunol Pract · vol. 4 · número 5 · págs. 932–940
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Asthma and respiratory diseases · Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- broccoli sprouts, sulforaphane, asthma, airway inflammation, oxidative stress, antioxidant gene expression, exhaled nitric oxide, allergen sensitization, indoor allergens, eosinophilic inflammation, nasal epithelial cells, peripheral blood mononuclear cells, lung function, rhinitis, dietary intervention
- MeSH
- humans, brassica, asthma, nitric oxide, isothiocyanates, sulfoxides, glutamate-cysteine ligase, nad(p)h dehydrogenase (quinone), isoprostanes, cytokines, antioxidants, vital capacity, forced expiratory volume, double-blind method, gene expression, adult, female, male, nf-e2-related factor 2, heme oxygenase-1, young adult
10 autores
- Kuladeep R. Sudini🇺🇸Johns Hopkins University
- Gregory B. Diette🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Patrick N. Breysse🇺🇸Johns Hopkins University
- Meredith C. McCormack🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Deborah Bull🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Shyam S. Biswal🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Shuyan Zhai🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Nga Hong Brereton🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Roger D. Peng🇺🇸Johns Hopkins University
- Elizabeth Cotton Matsui🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Broccoli sprouts (BS) are the richest source of sulforaphane (SFN), which is a potent inducer of phase II enzymes, which play a critical role in preventing oxidative stress (OS) and inflammation.
Objectives
The objective of this study was to determine if ingestion of whole BS improves airway inflammatory and physiologic outcomes, and OS in adults with asthma and allergic sensitization to an indoor allergen.
Methods
The study is a double-blind, placebo-controlled, randomized trial to compare the effects of BS with placebo (alfalfa sprouts [AS]) on airway inflammation and markers of OS. Forty adults (aged 18-50 years) were randomized to eat either (a) 100 g of BS daily or (b) 100 g of AS daily for 3 days. Fractional exhaled nitric oxide (FENO), forced expiratory volume 1, nasal epithelial and PBMC gene expression, inflammatory and OS biomarkers, and symptoms were assessed both before and after ingestion of the sprouts. The primary outcome variable was the change in FENO. Secondary outcome measures included rhinitis and asthma symptoms, lung function, and OS and inflammatory biomarkers.
Results
BS ingestion for 3 consecutive days did not reduce FENO, despite resulting in a marked increase in serum SFN concentrations (21 vs 22 parts per billion, P = .76). Furthermore, BS consumption did not induce cytoprotective antioxidant genes in either PBMCs or nasal epithelial cells, reduce OS and inflammatory markers, or improve lung function.
Conclusions
Ingestion of whole BS for 3 days does not appear to improve eosinophilic pulmonary inflammation, inflammatory and OS biomarkers, or clinical features of asthma among atopic adults with asthma despite resulting in a marked increase in serum SFN levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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