Financiado en parte por Else Kröner-Fresenius-Stiftung, Else-Kröner-Fresenius-Stiftung
The effects of music therapy in patients with high-dose chemotherapy and stem cell support: a randomized pilot study
Tuinmann G, Preissler P, Böhmer H, Suling A, Bokemeyer C
Psycho-oncology · 30 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Else Kröner-Fresenius-Stiftung
- Empresa
- Else-Kröner-Fresenius-Stiftung
- Subvenciones
- Else Kröner-Fresenius-Stiftung (P23/10//A34/10); Else Kröner-Fresenius-Stiftung (P33/08//A19/08)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-05-05 · Psychooncology · vol. 26 · número 3 · págs. 377–384
- Editorial
- Wiley
- Citado
- 47 citas · más que el 91% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Music Therapy and Health · Cancer survivorship and care · Art Therapy and Mental Health
- Palabras clave
- music therapy, high-dose chemotherapy, autologous stem cell transplantation, quality of life, depression, anxiety, pain perception, chemotherapy toxicity, mucositis, antiemetics, aprepitant, immunological changes, IgA, T cells, natural killer cells, supportive care
- MeSH
- humans, neoplasms, antineoplastic combined chemotherapy protocols, treatment outcome, combined modality therapy, music therapy, hematopoietic stem cell transplantation, transplantation, autologous, pilot projects, quality of life, adult, aged, middle aged, female, male
5 autores
- Gert Tuinmann🇩🇪 · autor de correspondenciaStiftung Charité; Charité - Universitätsmedizin Berlin
- Pia Preißler🇩🇪University Medical Center Hamburg-Eppendorf; University Cancer Center Hamburg
- Hauke Böhmer🇩🇪University Medical Center Hamburg-Eppendorf; University Cancer Center Hamburg
- Anna Isabella Suling🇩🇪University Medical Center Hamburg-Eppendorf
- Carsten Bokemeyer🇩🇪University Medical Center Hamburg-Eppendorf; University Cancer Center Hamburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Patients with high dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) are highly distressed. Psycho-oncological support might be beneficial but is not routinely provided. Our aim was to investigate whether music therapy (MT) in addition to standard supportive treatment had any effect on quality of life, depression, anxiety, side effects of therapy, medication, and immunological changes during and within three months after HDC plus ASCT.
Methods
Patients (n = 66) with HDC plus ASCT were randomly assigned to either MT (Intervention Group = IG) or standard supportive treatment (Control Group = CG). Quality of life was measured by EORTC QLQ-C30. Depression and anxiety were measured by the HADS-D before transplantation, during and after the inpatient stay. In addition, adverse events (AE), medication, and immunological parameters were observed.
Results
There was no improvement of global quality of life for patients receiving additional MT, but their perception of pain significantly changed (p = 0.027). Patients were neither depressed nor anxious on admission, therefore no improvements were found. IG patients had less 3-4° toxicities (e.g., mucositis). Aprepitant for antiemetic therapy was administered significantly more often in the CG (p = 0.040). The IgA decline and T4 count was less in IG, T8, and NK count decreased most in IG. These findings failed significance.
Conclusions
MT may improve pain perception in patients receiving HDC plus ASCT. Additionally positive effects on toxicities, use of antiemetic medication, and immunological changes were observed. As some of these findings failed significance, studies with larger sample sizes are needed. Copyright © 2016 John Wiley & Sons, Ltd.
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