Raised serum 25-hydroxyvitamin D levels in patients with active diabetic foot ulcers
Afarideh M, Ghanbari P, Noshad S, Ghajar A, Nakhjavani M, Esteghamati A
The British journal of nutrition · 36 citas
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Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-04-08 · Br J Nutr · vol. 115 · número 11 · págs. 1938–1946
- Editorial
- Cambridge University Press
- Citado
- 59 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Diabetic Foot Ulcer Assessment and Management · Adipokines, Inflammation, and Metabolic Diseases · Exercise and Physiological Responses
- Palabras clave
- Medicine, Diabetes mellitus, Internal medicine, Diabetic foot, Type 2 diabetes, Gastroenterology, Logistic regression, Pathogenesis, Diabetic foot ulcer, Vitamin D and neurology, Endocrinology
- MeSH
- humans, diabetic foot, diabetes mellitus, type 2, vitamin d deficiency, inflammation, vitamin d, c-reactive protein, cytokines, logistic models, case-control studies, cross-sectional studies, adult, aged, middle aged, female, male, chemokine ccl2
6 autores
- Mohsen Afarideh🇮🇷Tehran University of Medical Sciences
- Parvaneh Ghanbari🇮🇷Tehran University of Medical Sciences
- Sina Noshad🇮🇷Tehran University of Medical Sciences
- Alireza Ghajar🇮🇷Tehran University of Medical Sciences
- Manouchehr Nakhjavani🇮🇷Tehran University of Medical Sciences
- Alireza Esteghamati🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Studies have emerged to demonstrate bidirectional changes in circulating cytokines of inflammation in active diabetic foot ulcers (DFU). To further expand the understanding of inflammatory status present in chronic active DFU, we comparatively assessed the associations of selected pro-inflammatory cytokines and 25-hydroxyvitamin D (25(OH)D) with the presence of DFU. In a cross-sectional setting, thirty patients with type 2 diabetes and active DFU matched with thirty control non-ulcerative patients with type 2 diabetes and twenty-eight healthy subjects underwent anthropometric and biochemical assessment of study parameters. Recruited patients with DFU were selected from the grade II active chronic DFU at the time of hospitalisation according to the University of Texas wound classification system. Patients with DFU and controls had comparable age, sexual distribution, diastolic blood pressure and TAG, LDL-cholesterol and glycated Hb. The trend changes from healthy controls towards DFU showed a significant increase for serum monocyte chemoattractant protein-1, IL-6, 25(OH)D and highly sensitive C-reactive protein and a decrease for IL-8. In the multivariate adjusted logistic regression model, 25(OH)D emerged as the only independent correlate of DFU (OR 2·194; 95 % CI 1·003, 4·415). Unprecedented increase of serum 25(OH)D in chronic active DFU is possibly related to a selective alteration in the inflammatory status. In particular, 25(OH)D and IL-8 seem to share a common pathway in the pathogenesis of diabetic foot.
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