Financiado en parte por Novo Nordisk Fonden
A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
Romu T, Vavruch C, Dahlqvist-Leinhard O, Tallberg J, Dahlström N, Persson A, Heglind M, Lidell ME, Enerbäck S, Borga M, Nystrom FH
Metabolism: clinical and experimental · 25 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Linköpings Universitet
- Gobierno
- Vetenskapsrådet
- Empresa
- Novo Nordisk Fonden
- Subvenciones
- Novo Nordisk Fonden (NNF14OC0010547)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2016-04-03 · Metabolism · vol. 65 · número 6 · págs. 926–934
- Editorial
- Elsevier BV
- Citado
- 40 citas · más que el 94% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Palabras clave
- Brown adipose tissue, Medicine, Animal science, Randomized controlled trial, Magnetic resonance imaging, Nuclear medicine, Ingestion, Adipose tissue, Surgery, Internal medicine, Biology, Radiology
- MeSH
- humans, magnetic resonance imaging, organ size, calorimetry, indirect, energy metabolism, thermogenesis, adult, female, male, adipose tissue, brown, cold temperature, young adult
11 autores
- Thobias Romu🇸🇪Linköping University
- Camilla Vavruch🇸🇪Linköping University
- Olof Dahlqvist-Leinhard🇸🇪Linköping University
- Joakim Tallberg🇸🇪Linköping University
- Nils Dahlström🇸🇪Linköping University
- Anders Persson🇸🇪Linköping University
- Mikael Heglind🇸🇪University of Gothenburg
- Martin E. Lidell🇸🇪University of Gothenburg
- Sven Enerbäck🇸🇪University of Gothenburg
- Magnus Borga🇸🇪Linköping University
- Fredrik Hans Nyström🇸🇪 · autor de correspondenciaLinköping University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.
Design
Randomized, open, parallel-group trial.
Methods
Healthy non-selected participants were randomized to achieve cold-exposure 1hour/day, or to avoid any sense of feeling cold, for 6weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).
Results
Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841±199 kCal/24h to 1795±213 kCal/24h, p=0.047 cold-activated MR from 1900±150 kCal/24h to 1793±215 kCal/24h, p=0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p=0.052). The difference between MR changes by the interventions between groups was statistically significant (p=0.008 at room temperature, p=0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥8days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175±0.015l to 0.0216±0.014l, p=0.049).
Conclusions
We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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