Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans
Roberts PA, Fox J, Peirce N, Jones SW, Casey A, Greenhaff PL
Amino acids · 37 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Gobierno
- Chemical Biological Defence and Human Sciences Domain of the UK MoD Corporate Research Programme
- Subvenciones
- Medical Research Council (MR/K00414X/1)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-05-19 · Amino Acids · vol. 48 · número 8 · págs. 1831–1842
- Editorial
- Springer Science+Business Media
- Citado
- 58 citas · más que el 89% de estudios similares · 2.8× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Sports Performance and Training
- Palabras clave
- Glycogen, Creatine, Internal medicine, Phosphocreatine, Endocrinology, Placebo, Ingestion, Medicine, Carbohydrate, GLUT4, Exercise physiology, Physical exercise, Insulin, Glucose transporter
- MeSH
- muscle, skeletal, humans, creatine, glycogen, dietary carbohydrates, muscle proteins, glucose tolerance test, gene expression regulation, physical endurance, adult, male
6 autores
- Paul A. Roberts🇬🇧University of Nottingham; Queen's Medical Centre
- John Fox🇬🇧University of Nottingham; Queen's Medical Centre
- Nicholas S. Peirce🇬🇧University of Nottingham; Queen's Medical Centre
- Simon Wyn Jones🇬🇧University of Nottingham; Queen's Medical Centre
- A. E. Casey🇬🇧Qinetiq (United Kingdom)
- Paul Leonard Greenhaff🇬🇧 · autor de correspondenciaUniversity of Nottingham; Queen's Medical Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Muscle glycogen availability can limit endurance exercise performance. We previously demonstrated 5 days of creatine (Cr) and carbohydrate (CHO) ingestion augmented post-exercise muscle glycogen storage compared to CHO feeding alone in healthy volunteers. Here, we aimed to characterise the time-course of this Cr-induced response under more stringent and controlled experimental conditions and identify potential mechanisms underpinning this phenomenon. Fourteen healthy, male volunteers cycled to exhaustion at 70 % VO2peak. Muscle biopsies were obtained at rest immediately post-exercise and after 1, 3 and 6 days of recovery, during which Cr or placebo supplements (20 g day(-1)) were ingested along with a prescribed high CHO diet (37.5 kcal kg body mass(-1) day(-1), >80 % calories CHO). Oral-glucose tolerance tests (oral-GTT) were performed pre-exercise and after 1, 3 and 6 days of Cr and placebo supplementation. Exercise depleted muscle glycogen content to the same extent in both treatment groups. Creatine supplementation increased muscle total-Cr, free-Cr and phosphocreatine (PCr) content above placebo following 1, 3 and 6 days of supplementation (all P < 0.05). Creatine supplementation also increased muscle glycogen content noticeably above placebo after 1 day of supplementation (P < 0.05), which was sustained thereafter. This study confirmed dietary Cr augments post-exercise muscle glycogen super-compensation, and demonstrates this occurred during the initial 24 h of post-exercise recovery (when muscle total-Cr had increased by <10 %). This marked response ensued without apparent treatment differences in muscle insulin sensitivity (oral-GTT, muscle GLUT4 mRNA), osmotic stress (muscle c-fos and HSP72 mRNA) or muscle cell volume (muscle water content) responses, such that another mechanism must be causative.
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