Low-Level Laser for Mitigation of Low Salivary Flow Rate in Head and Neck Cancer Patients Undergoing Radiochemotherapy: A Prospective Longitudinal Study
Gonnelli FA, Palma LF, Giordani AJ, Deboni AL, Dias RS, Segreto RA, Segreto HR
Photomedicine and laser surgery · 30 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-05-20 · Photomed Laser Surg · vol. 34 · número 8 · págs. 326–330
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 47 citas · más que el 87% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Oral health in cancer treatment · Salivary Gland Disorders and Functions
- Palabras clave
- low-level laser therapy, hyposalivation, head and neck cancer, chemoradiotherapy, radiation-induced xerostomia, salivary gland hypofunction
- MeSH
- humans, head and neck neoplasms, xerostomia, treatment outcome, longitudinal studies, prospective studies, adult, aged, middle aged, female, male, lasers, semiconductor, chemoradiotherapy, low-level light therapy
7 autores
- Fernanda Aurora Stabile Gonnelli🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Luiz Felipe Palma🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Adelmo José Giordani🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Aline Lima da Silva Deboni🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Rodrigo Souza Dias🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Roberto Araújo Segreto🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
- Helena Regina Cômodo Segreto🇧🇷Hospital São Paulo; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The present study aimed to assess the impact of low-level laser (LLL) on low salivary flow rate in patients undergoing radiochemotherapy (RT-CT) for head and neck cancer.
Background data
LLL has shown efficiency in preventing hyposalivation in patients under different pathological conditions, including those undergoing RT-CT.
Methods
During all RT-CT, 17 patients received laser therapy and 10 received clinical care only. An Indium-Gallium-Aluminum-Phosphorus diode laser was punctually used for intraoral (660 nm, 40 mW, 10 J/cm(2), illuminated area 0.04 cm(2), 10 sec) and extraoral irradiation (780 nm, 15 mW, 3.8 J/cm(2), illuminated area 0.04 cm(2), 10 sec), three times a week and on alternate days, for a total of 21 sessions. Unstimulated salivary flow rate was assessed before the first RT session (N0), at the 15th RT session (N15), at the last RT session (Nf), and at 30 (N30) and 90 days after the end of the oncologic treatment (N90).
Results
At N15, Nf, and N30, patients treated with LLL showed significantly higher averages of salivary flow rate when compared with patients receiving clinical care only.
Conclusions
LLL seems to be an efficient tool for mitigation of salivary hypofunction in patients undergoing RT for head and neck cancer.
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