Resistance Training and Co-supplementation with Creatine and Protein in Older Subjects with Frailty
Collins J, Longhurst G, Roschel H, Gualano B
The Journal of frailty & aging · 28 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-01-01 · J Frailty Aging · vol. 5 · número 2 · págs. 1–9
- Editorial
- Springer Science+Business Media
- Citado
- 37 citas · más que el 90% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Frailty in Older Adults
- Palabras clave
- resistance training, creatine supplementation, whey protein, protein supplementation, frailty, older adults, muscle function, grip strength, Timed Up and Go test, body composition, exercise safety, frailty interventions, aging, sarcopenia, functional performance, adverse events, feasibility and tolerability, exercise adaptation
- MeSH
- humans, creatine, absorptiometry, photon, drug monitoring, hand strength, treatment outcome, double-blind method, body composition, aging, dietary supplements, aged, female, male, resistance training, whey proteins
4 autores
- J. COLLINS🇧🇷Universidade de São Paulo
- Glynis Longhurst🇧🇷Universidade de São Paulo
- Hamilton Roschel
- Bruno Gualano
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Studies assessing the effects co-supplementation with creatine and protein, along with resistance training, in older individuals with frailty are lacking.
Objectives
This is an exploratory trial from the Pro-Elderly study ("Protein Intake and Resistance Training in Aging") aimed at gathering knowledge on the feasibility, safety, and efficacy of co-supplementation with creatine and protein supplementation, combined with resistance training, in older individuals with frailty.
Design
A 14-week, double-blind, randomized, parallel-group, placebo controlled exploratory trial.
Setting, participants
The subjects were randomly assigned to whey protein and creatine co-supplementation (WHEY+CR) or whey protein supplementation (WHEY) group. All subjects undertook a supervised exercise training program and were assessed at baseline and after 14 weeks.
Measurements
Muscle function, body composition, blood parameters, and self-reported adverse events were assessed.
Results
No interaction effects (between-group differences) were observed for any dependent variables (p > 0.05 for all). However, there were main time-effects in handgrip (WHEY+CR = 26.65 ± 31.29; WHEY = 13.84 ± 14.93 Kg; p = 0.0005), timed-up-and-go (WHEY+CR = -11.20 ± 9.37; WHEY = -17.76 ± 21.74 sec; p = 0.006), and timed-stands test (WHEY+CR = 47.50 ± 35.54; WHEY = 46.87 ± 24.23 reps; p = 0.0001), suggesting that WHEY+CR and WHEY were similarly effective in improving muscle function. All of the subjects showed improvements in at least two of the three functional tests, regardless of their treatments. Body composition and blood parameters were not changed (p > 0.05). No severe adverse effects were observed.
Conclusions
Co-supplementation with creatine and whey protein was well-tolerable and free of adverse events in older subjects with frailty undertaking resistance training. Creatine supplementation did not augment the adaptive effects of resistance training along with whey protein on body composition or muscle function in this population. Clinicaltrials.gov: NCT01890382.
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