Prenatal Fish Oil Supplementation and Allergy: 6-Year Follow-up of a Randomized Controlled Trial
Best KP, Sullivan T, Palmer D, Gold M, Kennedy DJ, Martin J, Makrides M
Pediatrics · 48 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-05-25 · Pediatrics · vol. 137 · número 6
- Editorial
- American Academy of Pediatrics
- Citado
- 79 citas · más que el 98% de estudios similares · 8.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Neonatal Respiratory Health Research · Pediatric health and respiratory diseases
- Palabras clave
- Medicine, Fish oil, Docosahexaenoic acid, Wheeze, Eicosapentaenoic acid, Allergy, Randomized controlled trial, Relative risk, Asthma, Pregnancy, Confidence interval, Polyunsaturated fatty acid, Pediatrics, Immunology, Internal medicine, Fatty acid, Fish <Actinopterygii>
- MeSH
- animals, humans, dermatophagoides farinae, prenatal exposure delayed effects, hypersensitivity, docosahexaenoic acids, eicosapentaenoic acid, immunoglobulin e, prenatal care, follow-up studies, pregnancy, dietary supplements, adult, child, female, male
7 autores
- Karen P Best🇦🇺Women's & Children's Health Research Institute; South Australian Health and Medical Research Institute
- Thomas Sullivan🇦🇺The University of Adelaide
- Debra Jane Palmer🇦🇺The University of Western Australia; Women's & Children's Health Research Institute
- Michael Gold
- Declan Kennedy🇦🇺Women's and Children's Hospital
- James A. Martin🇦🇺Women's and Children's Hospital
- Maria Makrides🇦🇺Women's & Children's Health Research Institute; South Australian Health and Medical Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objective
Evidence from randomized controlled trials in early infancy suggest that prenatal supplementation with Ω-3 (n-3) long-chain polyunsaturated fatty acids (LCPUFA) reduces the incidence of allergic disease characterized by an immunoglobulin E (IgE) response. We aimed to determine whether protective effects were evident in the 6-year-old offspring of women supplemented with n-3 rich fish oil during pregnancy.
Methods
Six-year follow-up of children (n = 706) with a family history of allergic disease from the Docosahexaenoic Acid to Optimize Mother Infant Outcome (DOMInO) trial. Women were randomly allocated to receive n-3 LCPUFA-rich fish oil capsules (800 mg/d docosahexaenoic acid DHA and 100mg/d eicosapentaenoic acid) or vegetable oil capsules (without n-3 LCPUFA). Allergic disease symptoms including eczema, wheeze, rhinitis, and rhino-conjunctivitis, were assessed using the International Study of Asthma and Allergies in Childhood questionnaire and sensitization to allergens was measured by skin prick test.
Results
There was no difference in the percentage of children with any IgE-associated allergic disease between the n-3 LCPUFA and control groups (116/367 [31.5%] vs 106/336 [31.5%]; adjusted relative risk, 1.04; 95% confidence interval, 0.82-1.33; P = .73). There was a reduction in the percentage of children sensitized to house dust mite Dermatophagoides farinae (49/367 [13.4%] vs 68/336 [20.3%]; adjusted relative risk, 0.67, 95% confidence interval, 0.44-1.00; P = .0495).
Conclusions
Prenatal n-3 LCPUFA supplementation did not reduce IgE-associated allergic disease at 6 years of age. Secondary outcomes were suggestive of a protective effect of the intervention on the incidence of D. farinae sensitization.
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