Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies
Chen GC, Tong X, Xu JY, Han SF, Wan ZX, Qin JB, Qin LQ
The American journal of clinical nutrition · 106 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-05-26 · Am J Clin Nutr · vol. 104 · número 1 · págs. 164–172
- Editorial
- Elsevier BV
- Citado
- 167 citas · más que el 94% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Food composition and properties · Nutrition, Health, and Society Studies
- Palabras clave
- whole grain intake, whole grain products, all-cause mortality, cardiovascular mortality, cancer mortality, ischemic heart disease mortality, stroke mortality, dose-response relationship, nonlinear relationship
- MeSH
- humans, neoplasms, cardiovascular diseases, myocardial ischemia, diet, cause of death, feeding behavior, adolescent, adult, aged, middle aged, female, male, young adult, whole grains
7 autores
- Guo‐Chong Chen
- Xing Tong
- Jiaying Xu
- Shu-Fen Han
- Zhongxiao Wan
- Jiabi Qin🇨🇳Hunan Provincial Maternal and Child Health Hospital
- Li‐Qiang Qin🇨🇳 · autor de correspondenciaSoochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The potential role of whole grain in preventing various mortality outcomes has been inconsistently reported in a wealth of prospective observational studies.
Objective
We evaluated the relations between whole-grain intake and risks of dying from any cause, cardiovascular disease (CVD), and cancer through a meta-analytic approach.
Design
Relevant studies were identified by searching PubMed and EMBASE databases and bibliographies of retrieved full publications. Summary RRs with 95% CIs were calculated with a random-effects model.
Results
Thirteen studies on total mortality (104,061 deaths), 12 on CVD mortality (26,352 deaths), and 8 on cancer mortality (34,797 deaths) were included. Three studies reported whole-grain intake, and the remaining studies reported whole-grain product intake. In the dose-response analysis in which the intake of whole-grain products was converted to the amount of whole grain, the summary RRs for an increment in whole-grain intake of 50 g/d were 0.78 (95% CI: 0.67, 0.91) for total mortality, 0.70 (95% CI: 0.61, 0.79) for CVD mortality, and 0.82 (95% CI: 0.69, 0.96) for cancer mortality. A similar reduction was observed for the mortality from ischemic heart disease (RR: 0.68; 95% CI: 0.55, 0.84) but not from stroke (RR: 0.93; 95% CI: 0.54, 1.62). There was evidence of nonlinear associations of whole-grain intake with total (P-nonlinearity < 0.001) and CVD mortality (P-nonlinearity <0.001), but not with cancer mortality (P-nonlinearity = 0.12), with the curves for the associations appearing slightly steeper at lower ranges (<35 g/d) of the intake than at higher ranges.
Conclusions
Our findings suggest significant inverse relations between whole-grain intake and mortality due to any cause, CVD, or cancer. The findings support the recommendation of increasing whole-grain intake to improve public health.
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