Plasma 25-Hydroxyvitamin D, Vitamin D Binding Protein, and Risk of Colorectal Cancer in the Nurses' Health Study
Song M, Konijeti GG, Yuan C, Ananthakrishnan AN, Ogino S, Fuchs CS, Giovannucci EL, Ng K, Chan AT
Cancer prevention research (Philadelphia, Pa.) · 35 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (P01 CA055075.); National Cancer Institute (K07CA148894); National Cancer Institute (P01 CA087969); National Cancer Institute (UM1 CA186107); National Cancer Institute (R01CA169141); National Cancer Institute (R35CA197735); National Cancer Institute (R01‐CA049449); National Cancer Institute (R01-CA137178); National Cancer Institute (P50-CA127003); National Institute of Diabetes and Digestive and Kidney Diseases (K24 [DK]098311); National Cancer Institute (R01-CA151993)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2016-05-31 · Cancer Prev Res (Phila) · vol. 9 · número 8 · págs. 664–672
- Editorial
- American Association for Cancer Research
- Citado
- 45 citas · más que el 96% de estudios similares · 5.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Intestinal and Peritoneal Adhesions
- Palabras clave
- Colorectal cancer, Vitamin D and neurology, Medicine, Cancer, Cancer prevention, Vitamin, Internal medicine, Oncology
- MeSH
- humans, colorectal neoplasms, vitamin d, vitamin d-binding protein, odds ratio, risk factors, cohort studies, polymorphism, single nucleotide, adult, aged, middle aged, female, biomarkers, tumor
9 autores
- Mingyang Song🇺🇸Harvard University; Massachusetts General Hospital
- Gauree Gupta Konijeti🇺🇸Scripps Research Institute; Scripps Clinic
- Chen Yuan🇺🇸Harvard University
- Ashwin N. Ananthakrishnan🇺🇸Massachusetts General Hospital
- Shuji Ogino🇺🇸Brigham and Women's Hospital; Harvard University; Dana-Farber Cancer Institute
- Charles S. Fuchs🇺🇸Brigham and Women's Hospital; Dana-Farber Cancer Institute
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Kimmie Ng🇺🇸Dana-Farber Cancer Institute
- Andrew Tan Chan🇺🇸 · autor de correspondenciaBroad Institute; Brigham and Women's Hospital; Massachusetts General Hospital; Massachusetts Institute of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Total circulating 25-hydroxyvitamin D [25(OH)D)] has been associated with lower risk of colorectal cancer. The physiologic mechanism, however, may be more directly related to the free or bioavailable fraction of 25(OH)D, which is influenced by levels of vitamin D binding protein (VDBP). We assessed the association of prediagnosis total, free, and bioavailable 25(OH)D and VDBP with colorectal cancer risk among predominantly white women in the Nurses' Health Study (NHS) who provided a blood specimen in 1989-1990. We documented 378 cases of colorectal cancer through 2011 and matched them to 689 controls according to age and time of blood draw. We genotyped two common polymorphisms in the gene coding VDBP and calculated free and bioavailable 25(OH)D levels based on total 25(OH)D, VDBP, albumin, and their estimated genotype-specific binding affinities. Total 25(OH)D was associated with lower colorectal cancer risk (P for trend = 0.01). Compared with women in the lowest quintile of total 25(OH)D, those in the highest quintile had a multivariable-adjusted odds ratio (OR) for colorectal cancer of 0.54 [95% confidence interval (CI), 0.33-0.87]. Comparing extreme quintiles, we did not find any significant association with risk of colorectal cancer for VDBP (OR, 0.98; 95% CI, 0.65-1.47), free 25(OH)D (OR, 0.71; 95% CI, 0.46-1.10), or bioavailable 25(OH)D (OR, 0.92; 95% CI, 0.60-1.42). In conclusion, prediagnosis levels of total, but not free or bioavailable 25(OH)D, were associated with lower colorectal cancer risk. Although our findings support an inverse association of vitamin D with colorectal cancer, this association does not appear to be due to the unbound or bioavailable fraction of circulating vitamin D. Cancer Prev Res; 9(8); 664-72. ©2016 AACR.
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