The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial
Arden NK, Cro S, Sheard S, Doré CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, Macgregor A, Birrell F, Keen R
Osteoarthritis and cartilage · 102 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Oxford
- Universidad u hospital
- National Institute for Health Research Southampton Biomedical Research Centre
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- Medical Research Council (MR/K006312/1); National Institute for Health and Care Research (NF-SI-0508-10082); Medical Research Council (MC_UU_12011/1); National Institute for Health and Care Research (NF-SI-0513-10085)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2016-06-03 · Osteoarthritis Cartilage · vol. 24 · número 11 · págs. 1858–1866
- Editorial
- Elsevier BV
- Citado
- 135 citas · más que el 99% de estudios similares · 14.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Osteoarthritis Treatment and Mechanisms · Vitamin D Research Studies · Musculoskeletal pain and rehabilitation
- Palabras clave
- vitamin D supplementation, vitamin D3, knee osteoarthritis, joint space narrowing, radiographic progression, WOMAC, Kellgren-Lawrence grade, functional disability, older adults
- MeSH
- knee joint, humans, osteoarthritis, knee, vitamins, vitamin d, double-blind method
13 autores
- N K Arden🇬🇧 · autor de correspondenciaSouthampton General Hospital; University of Oxford; MRC Lifecourse Epidemiology Unit; University of Southampton; Arthritis Research UK
- Suzie Cro🇬🇧 · autor de correspondenciaMRC Clinical Trials Unit at UCL; University College London
- S. Sheard🇬🇧 · autor de correspondenciaUniversity of Oxford
- Caroline J Doré🇬🇧 · autor de correspondenciaMRC Clinical Trials Unit at UCL; University College London
- Anna Bara🇬🇧 · autor de correspondenciaMRC Clinical Trials Unit at UCL; University College London
- Susan Tebbs🇬🇧 · autor de correspondenciaMRC Clinical Trials Unit at UCL; University College London
- D.J. Hunter🇬🇧 · autor de correspondenciaUniversity of Oxford
- Sabrina James🇬🇧 · autor de correspondenciaSt Richard's Hospital
- Cyrus C. Cooper🇬🇧 · autor de correspondenciaSouthampton General Hospital; University of Oxford; MRC Lifecourse Epidemiology Unit; University of Southampton
- Terence W O’Neill🇬🇧 · autor de correspondenciaManchester Academic Health Science Centre; University of Manchester; Arthritis Research UK
- Alex J. MacGregor🇬🇧 · autor de correspondenciaUniversity of East Anglia
- Fraser N Birrell🇬🇧 · autor de correspondenciaNewcastle University
- Richard W. Keen🇬🇧 · autor de correspondenciaRoyal National Orthopaedic Hospital; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression.
Method
A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren & Lawrence grade, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, stiffness and the Get up and Go test.
Results
Vitamin D supplementation increased 25-OH-D3 from an average of 20.7 (standard deviation (SD) 8.9) μg/L to 30.4 (SD 7.7) μg/L, compared to 20.7 (SD 8.1) μg/L and 20.3 (SD 8.1) μg/L in the placebo group. There was no significant difference in the rate of JSN over 3 years in the medial compartment of the index knee between the treatment group (average -0.01 mm/year) and placebo group (-0.08 mm/year), average difference 0.08 mm/year (95% confidence interval (CI) [-0.14-0.29], P = 0.49). No significant interaction was found between baseline vitamin D levels and treatment effect. There were no significant differences for any of the secondary outcome measures.
Conclusion
Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a 3-year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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