Passive heat therapy improves endothelial function, arterial stiffness and blood pressure in sedentary humans
Brunt VE, Howard MJ, Francisco MA, Ely BR, Minson CT
The Journal of physiology · 240 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (T32 HL-007822); American Heart Association (14PRE20380300)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2016-06-08 · J Physiol · vol. 594 · número 18 · págs. 5329–5342
- Editorial
- Wiley
- Citado
- 313 citas · más que el 99% de estudios similares · 15.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Cardiovascular Health and Disease Prevention · Exercise and Physiological Responses
- Palabras clave
- Arterial stiffness, Blood pressure, Cardiology, Medicine, Internal medicine
- MeSH
- brachial artery, carotid arteries, femoral artery, endothelium, vascular, humans, cardiovascular diseases, ultrasonography, doppler, blood pressure, vasodilation, adult, female, male, hot temperature, young adult, carotid intima-media thickness, vascular stiffness, sedentary behavior
5 autores
- Vienna Elizabeth Brunt🇺🇸University of Oregon
- Matthew J. Howard🇺🇸University of Oregon
- Michael A. Francisco🇺🇸University of Oregon
- Brett Romano Ely🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸 · autor de correspondenciaUniversity of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Key points
A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular-related and all-cause mortality; however, the specific cardiovascular adaptations that cause this chronic protection are currently unknown. We investigated the effects of 8 weeks of repeated hot water immersion ('heat therapy') on various biomarkers of cardiovascular health in young, sedentary humans. We showed that, relative to a sham group which participated in thermoneutral water immersion, heat therapy increased flow-mediated dilatation, reduced arterial stiffness, reduced mean arterial and diastolic blood pressure, and reduced carotid intima media thickness, with changes all on par or greater than what is typically observed in sedentary subjects with exercise training. Our results show for the first time that heat therapy has widespread and robust effects on vascular function, and as such, could be a viable treatment option for improving cardiovascular health in a variety of patient populations, particularly those with limited exercise tolerance and/or capabilities.
Abstract
The majority of cardiovascular diseases are characterized by disorders of the arteries, predominantly caused by endothelial dysfunction and arterial stiffening. Intermittent hot water immersion ('heat therapy') results in elevations in core temperature and changes in cardiovascular haemodynamics, such as cardiac output and vascular shear stress, that are similar to exercise, and thus may provide an alternative means of improving health which could be utilized by patients with low exercise tolerance and/or capabilities. We sought to comprehensively assess the effects of 8 weeks of heat therapy on biomarkers of vascular function in young, sedentary subjects. Twenty young, sedentary subjects were assigned to participate in 8 weeks (4-5 times per week) of heat therapy (n = 10; immersion in a 40.5°C bath sufficient to maintain rectal temperature ≥ 38.5°C for 60 min per session) or thermoneutral water immersion (n = 10; sham). Eight weeks of heat therapy increased flow-mediated dilatation from 5.6 ± 0.3 to 10.9 ± 1.0% (P < 0.01) and superficial femoral dynamic arterial compliance from 0.06 ± 0.01 to 0.09 ±0.01 mm(2) mmHg(-1) (P = 0.03), and reduced (i.e. improved) aortic pulse wave velocity from 7.1 ± 0.3 to 6.1 ± 0.3 m s(-1) (P = 0.03), carotid intima media thickness from 0.43 ± 0.01 to 0.37 ± 0.01 mm (P < 0.001), and mean arterial blood pressure from 83 ± 1 to 78 ± 2 mmHg (P = 0.02). No changes were observed in the sham group or for carotid arterial compliance, superficial femoral intima media thickness or endothelium-independent dilatation. Heat therapy improved endothelium-dependent dilatation, arterial stiffness, intima media thickness and blood pressure, indicating improved cardiovascular health. These data suggest heat therapy may provide a simple and effective tool for improving cardiovascular health in various populations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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