A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
Allaire J, Couture P, Leclerc M, Charest A, Marin J, Lépine MC, Talbot D, Tchernof A, Lamarche B
The American journal of clinical nutrition · 193 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Subvenciones
- Canadian Institutes of Health Research (123494_1)
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-06-09 · Am J Clin Nutr · vol. 104 · número 2 · págs. 280–287
- Editorial
- Elsevier BV
- Citado
- 251 citas · más que el 100% de estudios similares · 22.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, inflammatory markers, IL-18, adiponectin, C-reactive protein, interleukin-6, TNF-α, triglycerides, HDL cholesterol, LDL cholesterol, abdominal obesity, cardiovascular risk, sex differences
- MeSH
- humans, inflammation, cholesterol, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, tumor necrosis factor-alpha, c-reactive protein, interleukin-18, cytokines, cross-over studies, double-blind method, dietary supplements, adult, aged, middle aged, female, male, adiponectin, biomarkers
9 autores
- Janie Allaire🇨🇦Institut sur la nutrition et les aliments fonctionnels (INAF)
- Patrick Couture🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Myriam Leclerc🇨🇦Institut sur la nutrition et les aliments fonctionnels (INAF)
- Amélie Charest🇨🇦Institut sur la nutrition et les aliments fonctionnels (INAF)
- Johanne Marin🇨🇦Institut sur la nutrition et les aliments fonctionnels (INAF)
- Marie-Claude Lépine🇨🇦Institut sur la nutrition et les aliments fonctionnels (INAF)
- Denis Charles Talbot🇨🇦Université Laval
- André Tchernof🇨🇦Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Benoı̂t Lamarche🇨🇦 · autor de correspondenciaInstitut sur la nutrition et les aliments fonctionnels (INAF)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and proportions.
Objectives
We compared the effects of EPA supplementation with those of DHA supplementation (re-esterified triacylglycerol; 90% pure) on inflammation markers (primary outcome) and blood lipids (secondary outcome) in men and women at risk of cardiovascular disease.
Design
In a double-blind, randomized, crossover, controlled study, healthy men (n = 48) and women (n = 106) with abdominal obesity and low-grade systemic inflammation consumed 3 g/d of the following supplements for periods of 10 wk: 1) EPA (2.7 g/d), 2) DHA (2.7 g/d), and 3) corn oil as a control with each supplementation separated by a 9-wk washout period. Primary analyses assessed the difference in cardiometabolic outcomes between EPA and DHA.
Results
Supplementation with DHA compared with supplementation with EPA led to a greater reduction in interleukin-18 (IL-18) (-7.0% ± 2.8% compared with -0.5% ± 3.0%, respectively; P = 0.01) and a greater increase in adiponectin (3.1% ± 1.6% compared with -1.2% ± 1.7%, respectively; P < 0.001). Between DHA and EPA, changes in CRP (-7.9% ± 5.0% compared with -1.8% ± 6.5%, respectively; P = 0.25), IL-6 (-12.0% ± 7.0% compared with -13.4% ± 7.0%, respectively; P = 0.86), and tumor necrosis factor-α (-14.8% ± 5.1% compared with -7.6% ± 10.2%, respectively; P = 0.63) were NS. DHA compared with EPA led to more pronounced reductions in triglycerides (-13.3% ± 2.3% compared with -11.9% ± 2.2%, respectively; P = 0.005) and the cholesterol:HDL-cholesterol ratio (-2.5% ± 1.3% compared with 0.3% ± 1.1%, respectively; P = 0.006) and greater increases in HDL cholesterol (7.6% ± 1.4% compared with -0.7% ± 1.1%, respectively; P < 0.0001) and LDL cholesterol (6.9% ± 1.8% compared with 2.2% ± 1.6%, respectively; P = 0.04). The increase in LDL-cholesterol concentrations for DHA compared with EPA was significant in men but not in women (P-treatment × sex interaction = 0.046).
Conclusions
DHA is more effective than EPA in modulating specific markers of inflammation as well as blood lipids. Additional studies are needed to determine the effect of a long-term DHA supplementation per se on cardiovascular disease risk. This trial was registered at clinicaltrials.gov as NCT01810003.
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