Financiado en parte por Kaiser Permanente, Almond Board of California, California Walnut Commission, Nestle Foundation, Nestle Nutrition Institute
A Daily Snack Containing Leafy Green Vegetables, Fruit, and Milk before and during Pregnancy Prevents Gestational Diabetes in a Randomized, Controlled Trial in Mumbai, India
Sahariah SA, Potdar RD, Gandhi M, Kehoe SH, Brown N, Sane H, Coakley PJ, Marley-Zagar E, Chopra H, Shivshankaran D, Cox VA, Jackson AA, Margetts BM, Fall CH
The Journal of nutrition · 43 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Organización sin fines de lucro
- Bill and Melinda Gates Foundation
- Empresa
- Kaiser Permanente
- Grupo de la industria
- Almond Board of California
- Organización sin fines de lucro
- Wellcome Trust
- Grupo de la industria
- California Walnut Commission
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- Korea National Institute of Health
- Organización sin fines de lucro
- Bill & Melinda Gates Foundation
- Gobierno
- USDA
- Gobierno
- NIH
- Empresa
- Nestle Foundation
- Organización sin fines de lucro
- Harvest Plus
- Empresa
- Nestle Nutrition Institute
- Subvenciones
- Wellcome Trust (074048); Medical Research Council (MR/M005186/1); Medical Research Council (MC_UU_12011/3)
Según 15 financiadores declarados.
Publicación
- Publicado
- 2016-06-09 · J Nutr · vol. 146 · número 7 · págs. 1453S–1460S
- Editorial
- Elsevier BV
- Citado
- 49 citas · más que el 97% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gestational Diabetes Research and Management · Maternal and Neonatal Healthcare · Nutritional Studies and Diet
- Palabras clave
- gestational diabetes mellitus, dietary intervention, leafy vegetables, fruits, milk, micronutrient intake, maternal diet, pregnancy, oral glucose tolerance test, 2-hour plasma glucose, low-income settings, Mumbai, birth weight, weight gain during pregnancy, oral antidiabetic drugs
- MeSH
- milk, animals, humans, fruit, vegetables, diabetes, gestational, pregnancy, india, female
14 autores
- Sirazul Ameen Sahariah
- Ramesh D. Potdar
- Meera Gandhi
- Sarah Helen Kehoe🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton
- Nick Brown🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton
- Harshad Sane
- Patsy Coakley🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton
- Ella Marley‐Zagar🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton
- Harsha Chopra
- Devi Shivshankaran
- Vanessa Cox🇬🇧MRC Lifecourse Epidemiology Unit; University of Southampton
- Alan A. Jackson🇬🇧NIHR Southampton Biomedical Research Centre; University of Southampton
- Barrie Margetts🇬🇧University of Southampton
- Caroline H. D. Fall🇬🇧 · autor de correspondenciaMRC Lifecourse Epidemiology Unit; University of Southampton
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Prospective observational studies suggest that maternal diets rich in leafy green vegetables and fruit may help prevent gestational diabetes mellitus (GDM).
Objective
Our objective was to test whether increasing women's dietary intake of leafy green vegetables, fruit, and milk before conception and throughout pregnancy reduced their risk of GDM.
Methods
Project SARAS ("excellent") (2006-2012) was a nonblinded, individually randomized, controlled trial in women living in slums in the city of Mumbai, India. The interventions included a daily snack made from leafy green vegetables, fruit, and milk for the treatment group or low-micronutrient vegetables (e.g., potato and onion) for the control group, in addition to the usual diet. Results for the primary outcome, birth weight, have been reported. Women were invited to take an oral-glucose-tolerance test (OGTT) at 28-32 wk gestation to screen for GDM (WHO 1999 criteria). The prevalence of GDM was compared between the intervention and control groups, and Kernel density analysis was used to compare distributions of 120-min plasma glucose concentrations between groups.
Results
Of 6513 women randomly assigned, 2291 became pregnant; of these, 2028 reached a gestation of 28 wk, 1008 (50%) attended for an OGTT, and 100 (9.9%) had GDM. In an intention-to-treat analysis, the prevalence of GDM was reduced in the treatment group (7.3% compared with 12.4% in controls; OR: 0.56; 95% CI: 0.36, 0.86; P = 0.008). The reduction in GDM remained significant after adjusting for prepregnancy adiposity and fat or weight gain during pregnancy. Kernel density analysis showed that this was explained by the fact that fewer women in the treatment group had a 2-h glucose concentration in the range 7.5-10.0 mmol/L.
Conclusions
In low-income settings, in which women have a low intake of micronutrient-rich foods, improving dietary micronutrient quality by increasing intake of leafy green vegetables, fruit, and/or milk may have an important protective effect against the development of GDM. This trial was registered at www.controlled-trials.com as ISRCTN62811278.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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