Whole Grain Intake and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Meta-Analysis of Prospective Cohort Studies
Zong G, Gao A, Hu FB, Sun Q
Circulation · 144 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (R01ES022981); National Heart, Lung, and Blood Institute (R00 HL098459); National Institute of Environmental Health Sciences (R01 ES021372)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2016-06-13 · Circulation · vol. 133 · número 24 · págs. 2370–2380
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 213 citas · más que el 100% de estudios similares · 19.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Food composition and properties · Celiac Disease Research and Management · Nutritional Studies and Diet
- Palabras clave
- Medicine, Relative risk, Confidence interval, Meta-analysis, Cancer, Internal medicine, Cohort study, National Health and Nutrition Examination Survey, Prospective cohort study, Population, Environmental health
- MeSH
- humans, neoplasms, cardiovascular diseases, diet, cohort studies, prospective studies, whole grains
4 autores
- Geng Zong🇺🇸Brigham and Women's Hospital; Harvard University
- Alisa Gao🇺🇸Brigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Qi Sun🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Current findings on associations between whole grain (WG) intake and mortality are inconsistent and have not been summarized by meta-analysis.
Methods and results
We searched for prospective cohort studies reporting associations between WG intake and mortality from all causes, cardiovascular disease (CVD), and cancer through February 2016 in Medline, Embase, and clinicaltrials.gov, and we further included unpublished results from National Health and Nutrition Examination Survey (NHANES) III and NHANES 1999 to 2004. Fourteen studies were eligible for analysis, which included 786 076 participants, 97 867 total deaths, 23 957 CVD deaths, and 37 492 cancer deaths. Pooled relative risks comparing extreme WG categories (high versus low) were 0.84 (95% confidence interval [CI], 0.80-0.88; P0.05). For each 16-g/d increase in WG (≈1 serving per d), relative risks of total, CVD, and cancer mortality were 0.93 (95% CI, 0.92-0.94; P<0.001), 0.91 (95% CI, 0.90-0.93; P<0.001), and 0.95 (95% CI, 0.94-0.96; P<0.001), respectively.
Conclusions
Our meta-analysis demonstrated inverse associations of WG intake with total and cause-specific mortality, and findings were particularly strong and robust for CVD mortality. These findings further support current Dietary Guidelines for Americans, which recommends at least 3 servings per day of WG intake.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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