Effect of the transdermal low-level laser therapy on endothelial function
Szymczyszyn A, Doroszko A, Szahidewicz-Krupska E, Rola P, Gutherc R, Jasiczek J, Mazur G, Derkacz A
Lasers in medical science · 22 citas
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Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-06-14 · Lasers Med Sci · vol. 31 · número 7 · págs. 1301–1307
- Editorial
- Springer Science+Business Media
- Citado
- 41 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Dermatologic Treatments and Research
- Palabras clave
- Angiogenesis, Nitric oxide, Endocrinology, Low level laser therapy, Vascular endothelial growth factor, Angiostatin, Transdermal, Medicine, Endothelial dysfunction, Internal medicine, Asymmetric dimethylarginine, Glutathione, Chemistry, Pharmacology, Arginine, Laser therapy, VEGF receptors, Laser, Biochemistry
- MeSH
- humans, nitric oxide, angiostatins, vascular endothelial growth factor a, fibroblast growth factors, arginine, glutathione, adult, female, male, lasers, semiconductor, low-level light therapy
8 autores
- Alicja Szymczyszyn🇵🇱Wroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Adrian Doroszko🇵🇱Wroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Ewa Szahidewicz-Krupska🇵🇱Wroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
- Piotr Rola🇵🇱Wroclaw Research Centre EIT+ (Poland)
- Radosław Gutherc🇵🇱Wroclaw Research Centre EIT+ (Poland)
- Jakub Jasiczek🇵🇱Wroclaw Research Centre EIT+ (Poland)
- Grzegorz J. Mazur🇵🇱Wroclaw Medical University
- Arkadiusz Derkacz🇵🇱 · autor de correspondenciaWroclaw Medical University; Wroclaw Research Centre EIT+ (Poland)
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of low-level laser therapy (LLLT) on the cardiovascular system is not fully established. Since the endothelium is an important endocrine element, establishing the mechanisms of LLLT action is an important issue.The aim of the study was to evaluate the effect of transdermal LLLT on endothelial function.In this study, healthy volunteers (n = 40, age = 20-40 years) were enrolled. N = 30 (14 female, 16 male, mean age 30 ± 5 years) constituted the laser-irradiated group (LG). The remaining 10 subjects (6 women, 4 men, mean age 28 ± 5 years) constituted the control group (CG). Participants were subjected to LLLT once a day for three consecutive days. Blood for biochemical assessments was drawn before the first irradiation and 24 h after the last session. In the LG, transdermal illumination of radial artery was conducted (a semiconductor laser λ = 808 nm, irradiation 50 mW, energy density 1.6 W/cm(2) and a dose 20 J/day, a total dose of 60 J). Biochemical parameters (reflecting angiogenesis: vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), angiostatin; antioxidative status: glutathione (GSH) and the nitric oxide metabolic pathway: symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA) and L-arginine) were assessed. In the LG, a significant increase in GSH levels and considerable decrease in angiostatin concentration following the LLLT were observed. No significant differences in levels of the VEGF, FGF, SDMA, ADMA were observed.LLLT modifies vascular endothelial function by increasing its antioxidant and angiogenic potential. We found no significant differences in levels of the nitric oxide pathway metabolites within 24 h following the LLLT irradiation.
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