Financiado en parte por U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial
Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, Bonnel EL, Woodhouse LR, Zunino SJ, Peerson JM, Lee JY, Rutledge JC, Hwang DH
The Journal of nutrition · 27 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institute of Food and Agriculture
- Gobierno
- Agricultural Research Service
- Gobierno
- Korea National Institute of Health
- Gobierno
- National Institute on Aging
- Gobierno
- USDA/NIFA
- Gobierno
- USDA
- Gobierno
- NIH
- Gobierno
- Western Human Nutrition Research Center
- Grupo de la industria
- US Highbush Blueberry Council
- Gobierno
- NIA NIH HHS
- Subvenciones
- Korea National Institute of Health (R01AG045541); National Institute of Food and Agriculture (2013‐03477); National Institute on Aging (R01 AG045541)
Según 12 financiadores declarados.
Publicación
- Publicado
- 2016-06-16 · J Nutr · vol. 146 · número 7 · págs. 1411–1419
- Editorial
- Elsevier BV
- Citado
- 48 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Fatty Acid Research and Health · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- postprandial inflammation, free fatty acids, blueberry powder, plant polyphenols, TLR2, monocyte activation, inflammatory cytokines, interleukin-6, IL-1β, interleukin-8, TNF-α, lipoprotein lipase, triglyceride-rich lipoproteins, saturated fatty acids, high-fat breakfast, dietary supplementation
- MeSH
- monocytes, humans, inflammation, dietary fats, fatty acids, nonesterified, cytokines, powders, cross-over studies, postprandial period, adult, meals, blueberry plants
13 autores
- Kikumi D. Ono‐Moore🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Ryan G. Snodgrass🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Shurong Huang🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center
- Shamsher Singh🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center
- Tammy L. Freytag🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center
- Dustin J. Burnett🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center
- Ellen L. Bonnel🇺🇸University of California, Davis
- Leslie R. Woodhouse🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center
- Susan J. Zunino🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Janet M Peerson🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
- Joo Young Lee🇰🇷Catholic University of Korea
- John C. Rutledge🇺🇸University of California, Davis
- Daniel H. Hwang🇺🇸 · autor de correspondenciaAgricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Saturated fatty acids (FAs) released from triglyceride-rich lipoproteins (TGRLs) activate Toll-like receptor 2 (TLR-2) and induce the expression of proinflammatory cytokines in monocytes. Certain plant polyphenols inhibit TLR-mediated signaling pathways.
Objective
We determined whether plasma free FAs (FFAs) after a moderately high-fat (MHF, 40% kcal from fat) breakfast modulate the inflammatory status of postprandial blood, and whether blueberry intake suppresses FFA-induced inflammatory responses in healthy humans.
Methods
Twenty-three volunteers with a mean ± SEM age and body mass index (in kg/m(2)) of 30 ± 3 y and 21.9 ± 0.4, respectively, consumed an MHF breakfast with either a placebo powder or 2 or 4 servings of blueberry powder in a randomized crossover design. The placebo powder was provided on the first test day and the blueberry powder doses were randomized with a 2-wk washout period. Plasma concentrations of lipids, glucose, and cytokines were determined. To determine whether FFAs derived from TGRL stimulate monocyte activation, and whether this is inhibited by blueberry intake, whole blood was treated with lipoprotein lipase (LPL).
Results
The median concentrations of FFAs and cytokines [tumor necrosis factor-α, interleukin (IL)-6 and IL-8] in postprandial plasma (3.5 h) decreased compared with fasting plasma regardless of the blueberry intake (P < 0.001 for FFAs and P < 0.05 for cytokines). However, concentrations of FFAs and cytokines including IL-1β increased in LPL-treated whole blood compared with untreated blood samples from participants who consumed the placebo powder. Blueberry intake suppressed IL-1β and IL-6 production in LPL-treated postprandial blood compared with the placebo control when fasting changes were used as a covariate.
Conclusions
The plasma FFA concentration may be an important determinant affecting inflammatory cytokine production in blood. Supplementation with blueberry powder did not affect plasma FFA and cytokine concentrations; however, it attenuated the cytokine production induced by ex vivo treatment of whole blood with LPL. This trial was registered at clinicaltrials.gov as NCT01594008.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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