Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties
Kuda O, Brezinova M, Rombaldova M, Slavikova B, Posta M, Beier P, Janovska P, Veleba J, Kopecky J, Kudova E, Pelikanova T, Kopecky J
Diabetes · 150 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Grantová Agentura České Republiky
- Universidad u hospital
- Akademie Věd České Republiky
- Gobierno
- Ministry of Education, Youth and Sports of the Czech Republic
- Gobierno
- Czech Science Foundation
- Subvenciones
- Grantová Agentura České Republiky (14-3684G)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2016-06-16 · Diabetes · vol. 65 · número 9 · págs. 2580–2590
- Editorial
- American Diabetes Association
- Citado
- 186 citas · más que el 99% de estudios similares · 10.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Eicosanoids and Hypertension Pharmacology · Peroxisome Proliferator-Activated Receptors
- Palabras clave
- Docosahexaenoic acid, Fatty acid, Polyunsaturated fatty acid, Chemistry, Biochemistry
- MeSH
- cells, cultured, 3t3-l1 cells, adipocytes, animals, mice, inbred c57bl, humans, mice, diabetes mellitus, type 2, insulin resistance, obesity, inflammation, esters, lipopolysaccharides, docosahexaenoic acids, fatty acids, unsaturated, linoleic acid, anti-inflammatory agents, phagocytosis, macrophage activation, male, adipose tissue, white
12 autores
- Ondřej Kuda🇨🇿Czech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Marie Březinová🇨🇿Czech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Martina Rombaldová🇨🇿Czech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Barbora Slavı́ková🇨🇿Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Martin Pošta🇨🇿Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Petr Beier🇨🇿Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Petra Janovská🇨🇿Czech Academy of Sciences; Czech Academy of Sciences, Institute of Physiology
- Jiří Veleba🇨🇿Institute of Clinical and Experimental Medicine
- Ján Kopecký🇨🇿 · autor de correspondenciaCzech Academy of Sciences; Institute of Clinical and Experimental Medicine; Czech Academy of Sciences, Institute of Physiology
- Eva Kudová🇨🇿Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
- Terezie Pelikánová🇨🇿Institute of Clinical and Experimental Medicine
- Ján Kopecký🇨🇿 · autor de correspondenciaCzech Academy of Sciences; Institute of Clinical and Experimental Medicine; Czech Academy of Sciences, Institute of Physiology
Resumen
El texto original del estudio, en el idioma en que se publicó.
White adipose tissue (WAT) is a complex organ with both metabolic and endocrine functions. Dysregulation of all of these functions of WAT, together with low-grade inflammation of the tissue in obese individuals, contributes to the development of insulin resistance and type 2 diabetes. n-3 polyunsaturated fatty acids (PUFAs) of marine origin play an important role in the resolution of inflammation and exert beneficial metabolic effects. Using experiments in mice and overweight/obese patients with type 2 diabetes, we elucidated the structures of novel members of fatty acid esters of hydroxy fatty acids-lipokines derived from docosahexaenoic acid (DHA) and linoleic acid, which were present in serum and WAT after n-3 PUFA supplementation. These compounds contained DHA esterified to 9- and 13-hydroxyoctadecadienoic acid (HLA) or 14-hydroxydocosahexaenoic acid (HDHA), termed 9-DHAHLA, 13-DHAHLA, and 14-DHAHDHA, and were synthesized by adipocytes at concentrations comparable to those of protectins and resolvins derived from DHA in WAT. 13-DHAHLA exerted anti-inflammatory and proresolving properties while reducing macrophage activation by lipopolysaccharides and enhancing the phagocytosis of zymosan particles. Our results document the existence of novel lipid mediators, which are involved in the beneficial anti-inflammatory effects attributed to n-3 PUFAs, in both mice and humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.