A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control
Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, Guerrero-Romero F
Pharmacological research · 94 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-06-20 · Pharmacol Res · vol. 111 · págs. 272–282
- Editorial
- Elsevier BV
- Citado
- 156 citas · más que el 92% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 69 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Natural Antidiabetic Agents Studies · Trace Elements in Health
- Palabras clave
- magnesium supplementation, insulin sensitivity, glycemic control, insulin resistance, HOMA-IR, HbA1c, fasting blood glucose, insulin, diabetes mellitus
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, insulin, blood glucose, hypoglycemic agents, treatment outcome, time factors, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male, randomized controlled trials as topic, biomarkers, glycated hemoglobin
4 autores
- Luis E. Simental‐Mendía🇲🇽Mexican Social Security Institute
- Amirhossein Sahebkar🇮🇷🇦🇺Mashhad University of Medical Sciences; The University of Western Australia; Royal Perth Hospital
- Martha Rodríguez‐Morán🇲🇽Mexican Social Security Institute
- Fernando Guerrero‐Romero🇲🇽 · autor de correspondenciaMexican Social Security Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
A systematic review and meta-analysis was conducted to evaluate the effect of oral magnesium supplementation on insulin sensitivity and glucose control in both diabetic and non-diabetic individuals. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to November 25, 2015) to identify RCTs evaluating the effect of magnesium on insulin sensitivity and glucose control. A random-effects model and generic inverse variance method were used to compensate for the heterogeneity of studies. Publication bias, sensitivity analysis, and meta-regression assessments were conducted using standard methods. The impact of magnesium supplementation on plasma concentrations of glucose, glycated hemoglobin (HbA1c), insulin, and HOMA-IR index was assessed in 22, 14, 12 and 10 treatment arms, respectively. A significant effect of magnesium supplementation was observed on HOMA-IR index (WMD: -0.67, 95% CI: -1.20, -0.14, p=0.013) but not on plasma glucose (WMD: -0.20mmol/L, 95% CI: -0.45, 0.05, p=0.119), HbA1c (WMD: 0.018mmol/L, 95% CI: -0.10, 0.13, p=0.756), and insulin (WMD: -2.22mmol/L, 95% CI: -9.62, 5.17, p=0.556). A subgroup analysis comparing magnesium supplementation durations of <4 months versus ≥4 months, exhibited a significant difference for fasting glucose concentrations (p<0.001) and HOMA-IR (p=0.001) in favor of the latter subgroup. Magnesium supplementation for ≥4 months significantly improves the HOMA-IR index and fasting glucose, in both diabetic and non-diabetic subjects. The present findings suggest that magnesium may be a beneficial supplement in glucose metabolic disorders.
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