Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases
Yun EJ, Song KS, Shin S, Kim S, Heo JY, Kweon GR, Wu T, Park JI, Lim K
Oncotarget · 34 citas
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation
- Universidad u hospital
- Chungnam National University
- Gobierno
- Ministry of Science, ICT and Future Planning
- Gobierno
- National Research Foundation of Korea
Según 4 financiadores declarados.
Publicación
- Publicado
- 2016-06-23 · Oncotarget · vol. 7 · número 31 · págs. 49961–49971
- Editorial
- Impact Journals LLC
- Citado
- 47 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Cancer, Lipids, and Metabolism · Inflammatory mediators and NSAID effects · Fatty Acid Research and Health
- Palabras clave
- Breast cancer, Metastasis, Cancer research, Docosahexaenoic acid, Medicine, Metastatic breast cancer, Matrix metalloproteinase, Cancer, Lung cancer, In vivo, Internal medicine, Oncology, Biology, Fatty acid, Polyunsaturated fatty acid
- MeSH
- cell line, tumor, animals, mice, inbred c57bl, mice, transgenic, humans, mice, breast neoplasms, neoplasm invasiveness, neoplasm metastasis, disease progression, docosahexaenoic acids, dinoprostone, nf-kappa b, culture media, conditioned, apoptosis, cell proliferation, cell movement, cell survival, gene expression regulation, neoplastic, active transport, cell nucleus, female, cyclooxygenase 2, matrix metalloproteinase 2, matrix metalloproteinase 9, matrix metalloproteinase inhibitors
9 autores
- Eun-Jin Yun🇰🇷🇺🇸 · autor de correspondenciaChungnam National University; The University of Texas Southwestern Medical Center
- Kyung-Sub Song🇺🇸🇰🇷 · autor de correspondenciaTulane University; Chungnam National University
- Soyeon Shin🇰🇷Chungnam National University
- Soyeon Kim🇰🇷Chungnam National University
- Jun Young Heo🇰🇷Chungnam National University
- Gi‐Ryang Kweon🇰🇷Chungnam National University
- Tong Wu🇺🇸Tulane University
- Jong‐Il Park🇰🇷Chungnam National University
- Kyu Lim🇰🇷Chungnam National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Breast cancer is one of the most prevalent cancers in women, and nearly half of breast cancer patients develop distant metastatic disease after therapy. Despite the significant advances that have been achieved in understanding breast cancer metastasis in the past decades, metastatic cancer is still hard to cure. Here, we demonstrated an anti-cancer mechanism of docosahexaenoic acid (DHA) that suppressed lung metastasis in breast cancer. DHA could inhibit proliferation and invasion of breast cancer cells in vitro, and this was mainly through blocking Cox-2-PGE2-NF-κB-MMPs cascades. DHA treatment significantly decreased Cox-2 and NF-κB expression as well as nuclear translocation of NF-κB in MDA-MB-231 cells. In addition, DHA also reduced NF-κB binding to DNA which may lead to inactivation of MMPs. Moreover, in vivo studies using Fat-1 transgenic mice showed remarkable decrease of tumor growth and metastasis to EO771 cells to lung in DHA-rich environment. In conclusion, DHA attenuated breast cancer progression and lung metastasis in part through suppressing MMPs, and these findings suggest chemoprevention and potential therapeutic strategy to overcome malignant breast cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.