Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis
Caini S, Cattaruzza MS, Bendinelli B, Tosti G, Masala G, Gnagnarella P, Assedi M, Stanganelli I, Palli D, Gandini S
European journal of nutrition · 36 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-07-07 · Eur J Nutr · vol. 56 · número 1 · págs. 1–12
- Editorial
- Springer Science+Business Media
- Citado
- 73 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Nonmelanoma Skin Cancer Studies · Skin Protection and Aging
- Palabras clave
- non-melanoma skin cancer, coffee consumption, tea consumption, caffeine, decaffeinated coffee, green tea, basal cell carcinoma, sun protection, cancer risk
- MeSH
- humans, skin neoplasms, caffeine, risk factors, coffee, tea, observational studies as topic, basal cell carcinoma
10 autores
- Saverio Caini · autor de correspondencia
- Maria Sofia Cattaruzza🇮🇹Policlinico Umberto I; Sapienza University of Rome
- Benedetta Bendinelli
- Giulio Tosti🇮🇹European Institute of Oncology
- Giovanna Masala
- Patrizia Gnagnarella🇮🇹European Institute of Oncology
- Melania Assedi
- Ignazio Stanganelli🇮🇹Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
- Domenico Palli
- Sara Gandini🇮🇹European Institute of Oncology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Laboratory studies suggested that caffeine and other nutrients contained in coffee and tea may protect against non-melanoma skin cancer (NMSC). However, epidemiological studies conducted so far have produced conflicting results.
Methods
We performed a literature review and meta-analysis of observational studies published until February 2016 that investigated the association between coffee and tea intake and NMSC risk. We calculated summary relative risk (SRR) and corresponding 95 % confidence intervals (95 % CI) by using random effects with maximum likelihood estimation.
Results
Overall, 37,627 NMSC cases from 13 papers were available for analysis. Intake of caffeinated coffee was inversely associated with NMSC risk (SRR for those in the highest vs. lowest category of intake: 0.82, 95 % CI 0.75-0.89, I 2 = 48 %), as well as intake of caffeine (SRR 0.86, 95 % CI 0.80-0.91, I 2 = 48 %). In subgroup analysis, these associations were limited to the basal cell cancer (BCC) histotype. There was no association between intake of decaffeinated coffee (SRR 1.01, 95 % CI 0.85-1.21, I 2 = 0) and tea (0.88, 95 % CI 0.72-1.07, I 2 = 0 %) and NMSC risk. There was no evidence of publication bias affecting the results. The available evidence was not sufficient to draw conclusions on the association between green tea intake and NMSC risk.
Conclusions
Coffee intake appears to exert a moderate protective effect against BCC development, probably through the biological effect of caffeine. However, the observational nature of studies included, subject to bias and confounding, suggests taking with caution these results that should be verified in randomized clinical trials.
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