Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials
Zhang X, Li Y, Del Gobbo LC, Rosanoff A, Wang J, Zhang W, Song Y
Hypertension (Dallas, Tex. : 1979) · 161 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-07-12 · Hypertension · vol. 68 · número 2 · págs. 324–333
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 250 citas · más que el 100% de estudios similares · 16.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Confidence interval, Blood pressure, Placebo, Internal medicine, Randomized controlled trial, Meta-analysis, Diastole, Gastroenterology, Endocrinology
- MeSH
- humans, hypertension, magnesium, antihypertensive agents, blood pressure determination, blood pressure, dietary supplements, randomized controlled trials as topic
7 autores
- Xi Zhang🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Yufeng Li🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Liana C. Del Gobbo🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Andrea Rosanoff🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Jiawei Wang🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Wen Zhang🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
- Yiqing Song🇯🇵🇨🇦🇺🇸Fukushima Medical University; Douglas Mental Health University Institute; McGill University; Stanford University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The antihypertensive effect of magnesium (Mg) supplementation remains controversial. We aimed to quantify the effect of oral Mg supplementation on blood pressure (BP) by synthesizing available evidence from randomized, double-blind, placebo-controlled trials. We searched trials of Mg supplementation on normotensive and hypertensive adults published up to February 1, 2016 from MEDLINE and EMBASE databases; 34 trials involving 2028 participants were eligible for this meta-analysis. Weighted mean differences of changes in BP and serum Mg were calculated by random-effects meta-analysis. Mg supplementation at a median dose of 368 mg/d for a median duration of 3 months significantly reduced systolic BP by 2.00 mm Hg (95% confidence interval, 0.43-3.58) and diastolic BP by 1.78 mm Hg (95% confidence interval, 0.73-2.82); these reductions were accompanied by 0.05 mmol/L (95% confidence interval, 0.03, 0.07) elevation of serum Mg compared with placebo. Using a restricted cubic spline curve, we found that Mg supplementation with a dose of 300 mg/d or duration of 1 month is sufficient to elevate serum Mg and reduce BP; and serum Mg was negatively associated with diastolic BP but not systolic BP (all P<0.05). In the stratified analyses, a greater reduction in BP tended to be found in trials with high quality or low dropout rate (all P values for interaction <0.05). However, residual heterogeneity may still exist after considering these possible factors. Our findings indicate a causal effect of Mg supplementation on lowering BPs in adults. Further well-designed trials are warranted to validate the BP-lowering efficacy of optimal Mg treatment.
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