Taurine and magnesium supplementation enhances the function of endothelial progenitor cells through antioxidation in healthy men and spontaneously hypertensive rats
Katakawa M, Fukuda N, Tsunemi A, Mori M, Maruyama T, Matsumoto T, Abe M, Yamori Y
Hypertension research : official journal of the Japanese Society of Hypertension · 23 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Nihon University
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
- Subvenciones
- Ministry of Education, Culture, Sports, Science and Technology (2008-2012); Ministry of Education, Culture, Sports, Science and Technology (2014?2018); Nihon University (S1411018); Ministry of Education, Culture, Sports, Science and Technology (S1411018); Ministry of Education, Culture, Sports, Science and Technology (S0801033)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2016-07-14 · Hypertens Res · vol. 39 · número 12 · págs. 848–856
- Editorial
- Springer Nature
- Citado
- 36 citas · más que el 83% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Aldose Reductase and Taurine · Nitric Oxide and Endothelin Effects · Magnesium in Health and Disease
- Palabras clave
- taurine, magnesium supplementation, endothelial progenitor cells, oxidative stress, antioxidant activity, endothelial dysfunction, spontaneously hypertensive rats, high-salt diet, NADPH oxidase, lipid peroxidation, cardiovascular disease prevention, lifespan extension
- MeSH
- animals, rats, inbred shr, humans, rats, body weight, magnesium, thiobarbituric acid reactive substances, taurine, antioxidants, oxidative stress, blood pressure, adolescent, adult, male, young adult, endothelial progenitor cells
8 autores
- Mayumi Katakawa🇯🇵Nihon University
- Noboru Fukuda🇯🇵 · autor de correspondenciaNihon University
- Akiko Tsunemi🇯🇵Nihon University
- Mari Mori🇯🇵Mukogawa Women's University
- Takashi Maruyama🇯🇵Nihon University
- Tarô Matsumoto🇯🇵Nihon University
- Masanori Abe🇯🇵Nihon University
- Yukio Yamori🇯🇵Mukogawa Women's University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Endothelial damage is repaired by endothelial progenitor cells (EPCs), which are pivotal in preventing cardiovascular diseases and prolonging lifespan. The WHO Cardiovascular Diseases and Alimentary Comparison Study demonstrated that dietary taurine and magnesium (Mg) intake suppresses cardiovascular diseases. We herein evaluate the effects of taurine and Mg supplementation on EPC function and oxidative stress in healthy men and spontaneously hypertensive rats (SHRs). Healthy men received taurine (3 g per day) or Mg (340 mg per day) for 2 weeks. SHRs and Wistar-Kyoto (WKY) rats were housed with high-salt drinking water (1% NaCl). The SHRs received 3% taurine solution and/or a high-Mg (600 mg per 100 g) diet for 4 weeks. Their peripheral blood mononuclear cells were separated to quantify EPC colony formation. Oxidative stress markers in their peripheral blood were evaluated using a free radical analytical system and a thiobarbituric acid reactive substance (TBARS) assay. Taurine and Mg supplementation significantly increased EPC colony numbers and significantly decreased free radical levels and TBARS scores in healthy men. Taurine and Mg supplementation significantly increased EPC colony numbers and significantly decreased TBARS scores and free radical levels in SHRs. Nicotinamide adenine dinucleotide phosphate oxidase component mRNA expression was significantly higher in the renal cortex of salt-loaded SHRs than in WKY rats, in which it was suppressed by taurine and Mg supplementation. Taurine and Mg supplementation increased EPC colony formation in healthy men and improved impaired EPC function in SHRs through antioxidation, indicating that the dietary intake of taurine and Mg may prolong lifespan by preventing the progression of cardiovascular diseases.
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