The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat
Kasielski M, Eusebio MO, Pietruczuk M, Nowak D
Nutrition journal · 22 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Uniwersytet Łódzki
- Universidad u hospital
- Uniwersytet Medyczny w Lodzi
- Subvenciones
- Uniwersytet Medyczny w Lodzi (503/8-071-03/503-01)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-12-01 · Nutr J · vol. 15 · número 1 · pág. 68
- Editorial
- BioMed Central
- Citado
- 36 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Telomeres, Telomerase, and Senescence · Birth, Development, and Health · Nutritional Studies and Diet
- Palabras clave
- Telomere, Red meat, Medicine, Peripheral blood mononuclear cell, Clinical nutrition, Food science, Physiology, Internal medicine, Biology, Genetics, Pathology, Gene
- MeSH
- leukocytes, mononuclear, telomere, humans, fruit, vegetables, exercise, diet, prospective studies, cross-sectional studies, smoking, socioeconomic factors, beverages, dairy products, adolescent, adult, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, young adult, surveys and questionnaires, edible grain, red meat
4 autores
- Marek Kasielski🇵🇱 · autor de correspondenciaMedical University of Lodz
- Makandjou-Ola Eusebio🇵🇱Medical University of Lodz
- Mirosława Pietruczuk🇵🇱Medical University of Lodz
- Dariusz Nowak🇵🇱Medical University of Lodz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Repeated nucleotide sequences combined with proteins called telomeres cover chromosome ends and dictate cells lifespan. Many factors can modify telomere length, among them are: nutrition and smoking habits, physical activities and socioeconomic status measured by education level. The aim of the study was to determine the influence of above mentioned factors on peripheral blood mononuclear cells telomere length.
Methods
Study included 28 subjects (seven male and 21 female, age 18-65 years.), smokers and non-smokers without any serious health problems in past and present. Following a basic medical examination, patients completed the food frequency questionnaire with 17 foods and beverages most common groups and gave blood for testing. PBMC telomere length were measured with qualitative real-time Polymerase Chain Reaction (rtPCR) method and expressed as a T/S ratio.
Results
Among nine food types (cereal, fruits, vegetables, diary, red meat, poultry, fish, sweets and salty snacks) and eight beverages (juices, coffee, tea, mineral water, alcoholic- and sweetened carbonated beverages) only intake of red meat was related to T/S ratio. Individuals with increased consumption of red meat have had higher T/S ratio and the strongest significant differences were observed between consumer groups: "never" and "1-2 daily" (p = 0.02). Smoking habits, physical activity, LDL and HDL concentrations, and education level were not related to telomere length, directly or as a covariates.
Conclusions
Unexpected correlation of telomere length with the frequency of consumption of red meat indicates the need for further in-depth research and may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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