Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation
Brunt VE, Eymann TM, Francisco MA, Howard MJ, Minson CT
Journal of applied physiology (Bethesda, Md. : 1985) · 121 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Organización sin fines de lucro
- The Eugene and Clarissa Evonuk Memorial Foundation
- Organización sin fines de lucro
- American Heart Association (AHA)
- Organización sin fines de lucro
- The Ken and Kenda Singer Endowment
- Subvenciones
- National Heart, Lung, and Blood Institute (T32 HL-007822); American Heart Association (14PRE20380300)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2016-07-15 · J Appl Physiol (1985) · vol. 121 · número 3 · págs. 716–723
- Editorial
- American Physiological Society
- Citado
- 153 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Infrared Thermography in Medicine
- Palabras clave
- Microdialysis, Nitric oxide, Medicine, Microcirculation, Chemistry, Internal medicine, Endocrinology, Anesthesia
- MeSH
- microcirculation, skin, humans, nitric oxide, hyperthermia, induced, heating, vasodilation, adult, middle aged, female, male, skin physiological phenomena, sedentary behavior
5 autores
- Vienna Elizabeth Brunt🇺🇸University of Oregon
- Taylor M. Eymann🇺🇸University of Oregon
- Michael A. Francisco🇺🇸University of Oregon
- Matthew J. Howard🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸 · autor de correspondenciaUniversity of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Passive heat therapy (repeated hot tub or sauna use) reduces cardiovascular risk, but its effects on the mechanisms underlying improvements in microvascular function have yet to be studied. We investigated the effects of heat therapy on microvascular function and whether improvements were related to changes in nitric oxide (NO) bioavailability using cutaneous microdialysis. Eighteen young, sedentary, otherwise healthy subjects participated in 8 wk of heat therapy (hot water immersion to maintain rectal temperature ≥38.5°C for 60 min/session; n = 9) or thermoneutral water immersion (sham, n = 9), and participated in experiments before and after the 8-wk intervention in which forearm cutaneous hyperemia to 39°C local heating was assessed at three microdialysis sites receiving 1) Lactated Ringer's (Control), 2) N(ω)-nitro-l-arginine (l-NNA; nonspecific NO synthase inhibitor), and 3) 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol), a superoxide dismutase mimetic. The arm used for microdialysis experiments remained out of the water at all times. Data are means ± SE cutaneous vascular conductance (CVC = laser Doppler flux/mean arterial pressure), presented as percent maximal CVC (% CVCmax). Heat therapy increased local heating plateau from 42 ± 6 to 53 ± 6% CVCmax (P < 0.001) and increased NO-dependent dilation (difference in plateau between Control and l-NNA sites) from 26 ± 6 to 38 ± 4% CVCmax (P < 0.01), while no changes were observed in the sham group. When data were pooled across all subjects at 0 wk, Tempol had no effect on the local heating response (P = 0.53 vs. Control). There were no changes at the Tempol site across interventions (P = 0.58). Passive heat therapy improves cutaneous microvascular function by improving NO-dependent dilation, which may have clinical implications.
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