Noninvasive low-level laser therapy for thrombocytopenia
Zhang Q, Dong T, Li P, Wu MX
Science translational medicine · 46 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Defense
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- Department of Defense
- Gobierno
- /Air Force Office of Scientific Research Military Photomedicine Program
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- U.S. Department of Defense (FA95501310068); National Heart, Lung, and Blood Institute (R21 HL141016)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2016-07-27 · Sci Transl Med · vol. 8 · número 349 · pág. 349ra101
- Editorial
- American Association for the Advancement of Science
- Citado
- 62 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Medicinal plant effects and applications · Entomological Studies and Ecology
- Palabras clave
- Medicine, Low level laser therapy, Laser therapy, Internal medicine, Laser
- MeSH
- blood platelets, megakaryocytes, cells, cultured, animals, mice, inbred c57bl, humans, mice, mice, mutant strains, thrombocytopenia, antigens, cd34, flow cytometry, thrombopoiesis, low-level light therapy
4 autores
- Qi Zhang🇺🇸Harvard University; Massachusetts General Hospital
- Tingting Dong🇺🇸Harvard University; Massachusetts General Hospital
- Peiyu Li🇺🇸Harvard University; Massachusetts General Hospital
- Mei X. Wu🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital; Harvard–MIT Division of Health Sciences and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Thrombocytopenia is a common hematologic disorder that is managed primarily by platelet transfusions. We report here that noninvasive whole-body illumination with a special near-infrared laser cures acute thrombocytopenia triggered by γ-irradiation within 2 weeks in mice, as opposed to a 5-week recovery time required in controls. The low-level laser (LLL) also greatly accelerated platelet regeneration in the presence of anti-CD41 antibody that binds and depletes platelets, and prevented a severe drop in platelet count caused by a common chemotherapeutic drug. Mechanistically, LLL stimulated mitochondrial biogenesis specifically in megakaryocytes owing to polyploidy of the cells. LLL also protected megakaryocytes from mitochondrial injury and apoptosis under stress. The multifaceted effects of LLL on mitochondria bolstered megakaryocyte maturation; facilitated elongation, branching, and formation of proplatelets; and doubled the number of platelets generated from individual megakaryocytes in mice. LLL-mediated platelet biogenesis depended on megakaryopoiesis and was inversely correlated with platelet counts, which kept platelet biogenesis in check and effectively averted thrombosis even after repeated uses, in sharp contrast to all current agents that stimulate the differentiation of megakaryocyte progenitors from hematopoietic stem cells independently of platelet counts. This safe, drug-free, donor-independent modality represents a paradigm shift in the prophylaxis and treatment of thrombocytopenia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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