The Effects of Supplementation with p-Synephrine Alone and in Combination with Caffeine on Metabolic, Lipolytic, and Cardiovascular Responses during Resistance Exercise
Ratamess NA, Bush JA, Kang J, Kraemer WJ, Stohs SJ, Nocera VG, Leise MD, Diamond KB, Campbell SC, Miller HB, Faigenbaum AD
Journal of the American College of Nutrition · 30 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-08-02 · J Am Coll Nutr · vol. 35 · número 8 · págs. 657–669
- Editorial
- Taylor & Francis
- Citado
- 37 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Pharmacology and Obesity Treatment · Muscle metabolism and nutrition
- Palabras clave
- p-synephrine, caffeine, resistance training, lipolysis, fat oxidation, energy expenditure, oxygen consumption, heart rate, serum glycerol, free fatty acids, plasma glucose, dietary supplementation, cardiovascular response
- MeSH
- cardiovascular system, humans, synephrine, glycerol, caffeine, blood glucose, fatty acids, nonesterified, exercise, cross-over studies, double-blind method, metabolism, energy metabolism, lipolysis, oxygen consumption, heart rate, dietary supplements, adult, male, resistance training
11 autores
- Nicholas A. Ratamess🇺🇸 · autor de correspondenciaThe College of New Jersey
- Jill A. Bush🇺🇸The College of New Jersey
- Jie Kang🇺🇸The College of New Jersey
- William J. Kraemer🇺🇸The Ohio State University
- Sidney J. Stohs🇺🇸Creighton University
- Vincenzo G. Nocera🇺🇸The College of New Jersey
- Megan D. Leise🇺🇸The College of New Jersey
- Keith Brett Diamond🇺🇸The College of New Jersey
- Sara C. Campbell🇺🇸Rutgers, The State University of New Jersey
- Howard B. Miller
- Avery D. Faigenbaum🇺🇸The College of New Jersey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The purpose of this study was to examine the metabolic, lipolytic, and cardiovascular responses to supplementation with p-synephrine alone and in combination with caffeine during resistance exercise (RE).
Methods
Twelve healthy men performed a control RE protocol (6 × 10 repetitions of squats) and were randomly assigned (using a double-blind crossover design with random protocol sequencing) to a supplement sequence: p-synephrine (S; 100 mg), p-synephrine + caffeine (SCF; 100 mg of p-synephrine plus 100 mg of caffeine), or a placebo (P). Subjects reported to the lab at a standard time, consumed a supplement, sat quietly for 45 minutes, performed the RE protocol, and sat quietly for 30 minutes. Blood samples were collected at rest (T1), after sitting quietly for 45 minutes (T2), immediately following RE (T3), and 15 minutes (T4) and 30 minutes (T5) postexercise. Oxygen consumption (VO2) and heart rate (HR) data were collected throughout.
Results
Serum glycerol was significantly elevated at T2 only in S and SCF and T3 to T5 in all treatments. Nonesterified fatty acid (NEFA) concentrations did not differ between treatments. Plasma glucose was significantly elevated compared to T1 with highest area under the curve values seen in SCF. Mean VO2 and energy expenditure (EE) were significantly higher in S and SCF through 30 minutes postexercise. Fat oxidation rates favored S and SCF between 25 and 30 minutes postexercise. Mean HR during RE was significantly highest in SCF.
Conclusions
Supplementation with S and SCF increases lipolysis primarily at rest and increases VO2, EE, and fat oxidation rates 30 minutes following RE. No HR changes were observed unless caffeine was added.
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