Association between dietary nitrate and nitrite intake and sitespecific cancer risk: evidence from observational studies
Xie L, Mo M, Jia HX, Liang F, Yuan J, Zhu J
Oncotarget · 60 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-07-29 · Oncotarget · vol. 7 · número 35 · págs. 56915–56932
- Editorial
- Impact Journals LLC
- Citado
- 85 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 89 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Folate and B Vitamins Research · Sulfur Compounds in Biology
- Palabras clave
- Observational study, Medicine, Nitrite, Dietary Nitrate, Nitrate, Internal medicine, Environmental health, Oncology, Physiology, Biology, Ecology
- MeSH
- humans, neoplasms, nitrates, nitrites, diet, risk, algorithms, female, male, observational studies as topic
6 autores
- Li Xie🇨🇳 · autor de correspondenciaShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Miao Mo🇨🇳 · autor de correspondenciaShanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Huixun Jia🇨🇳Shanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Fei Liang🇨🇳Shanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Jing Yuan🇨🇳Shanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
- Ji Ye Zhu🇨🇳Shanghai Medical College of Fudan University; Fudan University Shanghai Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies have reported inconsistent findings on the association between dietary nitrate and nitrite intake and cancer risk. We performed a meta-analysis of epidemiological studies to summarize available evidence on the association between dietary nitrate and nitrite intake and cancer risk from published prospective and case-control studies. PubMed database was searched to identify eligible publications through April 30th, 2016. Study-specific relative risks (RRs) with corresponding 95% confidence interval (CI) from individual studies were pooled by using random- or fixed- model, and heterogeneity and publication bias analyses were conducted. Data from 62 observational studies, 49 studies for nitrates and 51 studies for nitrites, including a total of 60,627 cancer cases were analyzed. Comparing the highest vs. lowest levels, dietary nitrate intake was inversely associated with gastric cancer risk (RR = 0.78; 95%CI = 0.67-0.91) with moderate heterogeneity (I2 = 42.3%). In contrast, dietary nitrite intake was positively associated with adult glioma and thyroid cancer risk with pooled RR of 1.21 (95%CI = 1.03-1.42) and 1.52 (95%CI = 1.12-2.05), respectively. No significant associations were found between dietary nitrate/nitrite and cancers of the breast, bladder, colorectal, esophagus, renal cell, non-Hodgkin lymphoma, ovarian, and pancreas. The present meta-analysis provided modest evidence that positive associations of dietary nitrate and negative associations of dietary nitrite with certain cancers.
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