Evaluation of the efficacy of Withania somnifera (Ashwagandha) root extract in patients with obsessive-compulsive disorder: A randomized double-blind placebo-controlled trial
Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, Gholampour B, Mohammadpour AH, Sahebkar A
Complementary therapies in medicine · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Vice Chancellor of Research at the Mashhad University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2016-04-10 · Complement Ther Med · vol. 27 · págs. 25–29
- Editorial
- Elsevier BV
- Citado
- 48 citas · más que el 92% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Obsessive-Compulsive Spectrum Disorders · Medicinal Plant Extracts Effects
- Palabras clave
- Withania somnifera, ashwagandha root extract, obsessive-compulsive disorder, adjunctive therapy, selective serotonin reuptake inhibitors, serotonergic system, Yale-Brown Obsessive Compulsive Scale, herbal medicine
- MeSH
- humans, withania, plant roots, plant extracts, double-blind method, obsessive-compulsive disorder, adult, female, male
7 autores
- Seyedeh Pardis Jahanbakhsh🇮🇷Mashhad University of Medical Sciences
- Ali Akhondpour Manteghi🇮🇷Mashhad University of Medical Sciences
- Seyed Ahmad Emami🇮🇷Mashhad University of Medical Sciences
- Saman Mahyari🇮🇷Mashhad University of Medical Sciences
- Beheshteh Gholampour
- Amir Hooshang Mohammadpour🇮🇷 · autor de correspondenciaMashhad University of Medical Sciences
- Amirhossein Sahebkar🇮🇷🇦🇺Mashhad University of Medical Sciences; The University of Western Australia; Royal Perth Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder that is causally linked to dysregulation of the serotonergic system. The aim of this study is to investigate the efficacy of Withania somnifera (W. somnifera) root extract as an adjunct therapy to standard OCD treatment.
Methods
Thirty patients with a confirmed diagnosis of OCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria participated in this randomized double-blind placebo-controlled trial and were randomly assigned to the treatment group (W. somnifera extract, 120mg/day; n=15) or the placebo group (n=15). All patients were under treatment with Selective Serotonin Re-uptake Inhibitors (SSRIs), and were instructed to take 4 capsules of the extract or placebo per day, preferably after meals, for a period of six weeks. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used in order to assess the severity of OCD symptoms at baseline and at the end of the trial. Statistical analyses were performed using SPSS software and Y-BOCS values were presented as median and range (Min-Max).
Results
Comparison of the change in Y-BOCS score during the course of the trial revealed a significantly greater effect of W. somnifera (26 (14-40) [pre-treatment] versus 14 (4-40) [post-treatment]; change: -8 (-23 to 0)) versus placebo (18 (11-33) [pre-treatment] versus 16 (10-31) [post-treatment]; change: -2 (-4 to 0)) (P<0.001). The extract was safe and no adverse event was reported during the trial.
Conclusion
W. somnifera extract may be beneficial as a safe and effective adjunct to SSRIs in the treatment of OCD.
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