Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials
Veronese N, Watutantrige-Fernando S, Luchini C, Solmi M, Sartore G, Sergi G, Manzato E, Barbagallo M, Maggi S, Stubbs B
European journal of clinical nutrition · 94 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-08-17 · Eur J Clin Nutr · vol. 70 · número 12 · págs. 1354–1359
- Editorial
- Springer Nature
- Citado
- 152 citas · más que el 93% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Natural Antidiabetic Agents Studies · Magnesium Alloys: Properties and Applications
- Palabras clave
- magnesium supplementation, glucose metabolism, diabetes mellitus, prediabetes, insulin resistance, fasting blood glucose, oral glucose tolerance test, HOMA-IR, insulin sensitivity
- MeSH
- humans, diabetes mellitus, magnesium, blood glucose, glucose tolerance test, fasting, double-blind method, dietary supplements, adult, aged, middle aged, female, male, randomized controlled trials as topic
10 autores
- Nicola Veronese🇮🇹 · autor de correspondenciaUniversity of Padua
- Sara Watutantrige‐Fernando🇮🇹University of Padua
- Claudio Luchini🇮🇹University of Verona; Ospedale Santa Chiara
- Marco Solmi🇮🇹University of Padua
- Giovanni Sartore🇮🇹University of Padua
- Giuseppe Sergi🇮🇹University of Padua
- Enzo Manzato🇮🇹University of Padua; National Research Council
- Mario Barbagallo🇮🇹University of Palermo
- Stefania Maggi🇬🇧South London and Maudsley NHS Foundation Trust; Maudsley Hospital
- Brendon Stubbs🇬🇧King's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although higher dietary intakes of magnesium (Mg) seem to correspond to lower diabetes incidence, research concerning Mg supplementation in people with or at risk of diabetes is limited. Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. A literature search in PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Clinicaltrials.gov without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) investigating the effect of oral Mg supplementation vs placebo in patients with diabetes or at high risk of diabetes. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes with at least two studies; other outcomes were summarized descriptively. Eighteen RCTs (12 in people with diabetes and 6 in people at high risk of diabetes) were included. Compared with placebo (n=334), Mg treatment (n=336) reduced fasting plasma glucose (studies=9; SMD=-0.40; 95% CI: -0.80 to -0.00; I2=77%) in people with diabetes. In conditions in people at high risk of diabetes (Mg: 226; placebo=227 participants), Mg supplementation significantly improved plasma glucose levels after a 2 h oral glucose tolerance test (three studies; SMD=-0.35; 95% CI: -0.62 to -0.07; I2=0%) and demonstrated trend level reductions in HOMA-IR (homeostatic model assessment-insulin resistance; five studies; SMD=-0.57; 95% CI: -1.17 to 0.03; I2=88%). Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes.
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