Consumption of whole grains in relation to mortality from all causes, cardiovascular disease, and diabetes: Dose-response meta-analysis of prospective cohort studies
Li B, Zhang G, Tan M, Zhao L, Jin L, Tang X, Jiang G, Zhong K
Medicine · 37 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-08-01 · Medicine (Baltimore) · vol. 95 · número 33 · pág. e4229
- Editorial
- Wolters Kluwer
- Citado
- 57 citas · más que el 94% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-ND
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Palabras clave
- Medicine, Cohort study, Diabetes mellitus, Relative risk, Prospective cohort study, Internal medicine, Meta-analysis, Observational study, Cohort, Confidence interval, Stroke (engine), Endocrinology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, diet, mortality, risk factors, prospective studies, dose-response relationship, drug, stroke, whole grains
8 autores
- Bailing Li🇨🇳Second Military Medical University; Changhai Hospital
- Guanxin Zhang🇨🇳Second Military Medical University; Changhai Hospital
- Mengwei Tan🇨🇳Second Military Medical University; Changhai Hospital
- Libo Zhao🇨🇳Second Military Medical University; Changhai Hospital
- Lei Jin🇨🇳Second Military Medical University; Changhai Hospital
- Xiaojun Tang🇨🇳Second Military Medical University; Changhai Hospital
- Gengxi Jiang🇨🇳 · autor de correspondenciaSecond Military Medical University; Changhai Hospital
- Keng Zhong🇨🇳 · autor de correspondenciaSecond Military Medical University; Changhai Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
To investigate the correlation between consumption of whole grains and the risk of all-cause, cardiovascular disease (CVD), and diabetes-specific mortality according to a dose-response meta-analysis of prospective cohort studies.
Methods
Observational cohort studies, which reported associations between whole grains and the risk of death outcomes, were identified by searching articles in the MEDLINE, EMBASE, and the reference lists of relevant articles. The search was up to November 30, 2015. Data extraction was performed by 2 independent investigators, and a consensus was reached with involvement of a third.
Results
Ten prospective cohort studies (9 publications) were eligible in this meta-analysis. During follow-up periods ranging from 5.5 to 26 years, there were 92,647 deaths among 782,751 participants. Overall, a diet containing greater amounts of whole grains may be associated with a lower risk of all-cause, CVD-, and coronary heart disease (CHD)-specific mortality. The summary relative risks (RRs) were 0.93 (95% confidence intervals [CIs]: 0.91-0.95; Pheterogeneity < 0.001) for all-cause mortality, 0.95 (95% CIs: 0.92-0.98; Pheterogeneity < 0.001) for CVD-specific mortality, and 0.92 (95% CIs: 0.88-0.97; Pheterogeneity < 0.001) for CHD-specific mortality for an increment of 1 serving (30 g) a day of whole grain intake. The combined estimates were robust across subgroup and sensitivity analyses. Higher consumption of whole grains was not appreciably associated with risk of mortality from stroke and diabetes.
Conclusion
Evidence from observational cohort studies indicates inverse associations of intake of whole grains with risk of mortality from all-cause, CVD, and CHD. However, no associations with risk of deaths from stroke and diabetes were observed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-ND).
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