Almond supplementation reduces serum uric acid in coronary artery disease patients: a randomized controlled trial
Jamshed H, Gilani AU, Sultan FA, Amin F, Arslan J, Ghani S, Masroor M
Nutrition journal · 20 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Higher Education Commission, Pakistan
- Gobierno
- Higher Education Commission, Pakistan (PK)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2015-12-01 · Nutr J · vol. 15 · número 1 · pág. 77
- Editorial
- BioMed Central
- Citado
- 31 citas · más que el 81% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gout, Hyperuricemia, Uric Acid · Nuts composition and effects · Diet, Metabolism, and Disease
- Palabras clave
- serum uric acid, coronary artery disease, hyperuricemia, dietary intervention, renal failure, blood pressure, body weight
- MeSH
- humans, nuts, hyperuricemia, uric acid, diet, blood pressure, dietary supplements, middle aged, united states, pakistan, female, male, renal insufficiency, coronary artery disease, breakfast, biomarkers, prunus dulcis
7 autores
- Humaira Jamshed🇵🇰Aga Khan University
- Anwarul Hassan Gilani🇵🇰 · autor de correspondenciaAga Khan University; Government of Pakistan
- Fateh Ali Tipoo Sultan🇵🇰Aga Khan University
- Faridah Amin🇵🇰Aga Khan University
- Jamshed Arslan🇵🇰Aga Khan University
- Sumaira Ghani🇵🇰Aga Khan University
- Madiha Masroor🇵🇰Aga Khan University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Elevated serum uric acid (UA), a biomarker of renal insufficiency, is also an independent prognostic marker for morbidity in coronary artery disease (CAD) and poses serious health risks. This study reports the effect of almond consumption on UA in CAD patients.
Study design
A randomized controlled clinical trial was conducted with three groups: no-intervention (NI), Pakistani almonds (PA) or American almonds (AA). Patients were recruited from the Cardiology Clinics, Aga Khan University Hospital. Two follow-ups were scheduled at week-6 and week-12. 150 patients were randomly divided in three groups (50 per group). NI was not given almonds, whereas the PA and AA were given Pakistani and American almond varieties (10 g/day), respectively; with instruction to soak overnight and eat before breakfast.
Results
Almonds supplementation significantly reduced (p < 0.05) serum UA among groups, and over time. At week-6, UA concentrations were -13 to -16 % less in PA and AA; at week-12 the concentrations were -14 to -18 % less, compared to NI. Systolic and diastolic blood pressure and body weights of the participants remained fairly constant among all the groups.
Conclusion
Almonds (10 g/day), eaten before breakfast, reduces serum UA in CAD patients. Prevention of hyperuricemia can confer protection from kidney and vascular damage and if extrapolated for general population, dietary almonds can offer grander health benefit. Trial is registered at Australian New Zealand Clinical trial registry as ACTRN12614000036617.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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