A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease
Vijayakumar M, Vasudevan DM, Sundaram KR, Krishnan S, Vaidyanathan K, Nandakumar S, Chandrasekhar R, Mathew N
Indian heart journal · 50 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-01-14 · Indian Heart J · vol. 68 · número 4 · págs. 498–506
- Editorial
- Elsevier BV
- Citado
- 88 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Coconut Research and Applications · Nuts composition and effects · Fatty Acid Research and Health
- Palabras clave
- Medicine, Sunflower oil, Coconut oil, Coronary artery disease, Anthropometry, Lipid profile, Fish oil, Saturated fat, Internal medicine, Food science, Cholesterol, Cardiology, Pathology, Biology
- MeSH
- humans, coronary disease, lipids, dietary fats, plant oils, incidence, follow-up studies, pilot projects, single-blind method, time factors, middle aged, india, female, male, sunflower oil, coconut oil
8 autores
- Maniyal Vijayakumar🇮🇳 · autor de correspondenciaAmrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- DM Vasudevan🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- K. R. Sundaram🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Sajitha Krishnan🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Kannan Vaidyanathan🇮🇳Institute of Medical Sciences
- Sandya Nandakumar🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Rajiv Chandrasekhar🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
- Navin Mathew🇮🇳Amrita Institute of Medical Sciences and Research Centre; Amrita Vishwa Vidyapeetham
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and rationale
Coronary artery disease (CAD) and its pathological atherosclerotic process are closely related to lipids. Lipids levels are in turn influenced by dietary oils and fats. Saturated fatty acids increase the risk for atherosclerosis by increasing the cholesterol level. This study was conducted to investigate the impact of cooking oil media (coconut oil and sunflower oil) on lipid profile, antioxidant mechanism, and endothelial function in patients with established CAD.
Design and methods
In a single center randomized study in India, patients with stable CAD on standard medical care were assigned to receive coconut oil (Group I) or sunflower oil (Group II) as cooking media for 2 years. Anthropometric measurements, serum, lipids, Lipoprotein a, apo B/A-1 ratio, antioxidants, flow-mediated vasodilation, and cardiovascular events were assessed at 3 months, 6 months, 1 year, and 2 years.
Results
Hundred patients in each arm completed 2 years with 98% follow-up. There was no statistically significant difference in the anthropometric, biochemical, vascular function, and in cardiovascular events after 2 years.
Conclusion
Coconut oil even though rich in saturated fatty acids in comparison to sunflower oil when used as cooking oil media over a period of 2 years did not change the lipid-related cardiovascular risk factors and events in those receiving standard medical care.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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