Evidence from randomised controlled trials does not support current dietary fat guidelines: a systematic review and meta-analysis
Harcombe Z, Baker JS, DiNicolantonio JJ, Grace F, Davies B
Open heart · 42 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-08-01 · Open Heart · vol. 3 · número 2 · pág. e000409
- Editorial
- BMJ
- Citado
- 65 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- dietary fat, coronary artery disease, serum cholesterol, all-cause mortality, coronary heart disease mortality, dietary intervention, secondary prevention, primary prevention
5 autores
- Zoë Harcombe🇬🇧 · autor de correspondenciaUniversity of the West of Scotland
- Julien S. Baker🇬🇧University of the West of Scotland
- James J. DiNicolantonio🇺🇸Saint Luke's Hospital
- Fergal Grace🇬🇧University of the West of Scotland
- Bruce Davies🇬🇧University of South Wales
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
National dietary guidelines were introduced in 1977 and 1983, by the USA and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) mortality by reducing dietary fat intake. A recent systematic review and meta-analysis by the present authors, examining the randomised controlled trial (RCT) evidence available to the dietary committees during those time periods, found no support for the recommendations to restrict dietary fat. The present investigation extends our work by re-examining the totality of RCT evidence relating to the current dietary fat guidelines.
Methods
A systematic review and meta-analysis of RCTs currently available, which examined the relationship between dietary fat, serum cholesterol and the development of CHD, was undertaken.
Results
The systematic review included 62 421 participants in 10 dietary trials: 7 secondary prevention studies, 1 primary prevention and 2 combined. The death rates for all-cause mortality were 6.45% and 6.06% in the intervention and control groups, respectively. The risk ratio (RR) from meta-analysis was 0.991 (95% CI 0.935 to 1.051). The death rates for CHD mortality were 2.16% and 1.80% in the intervention and control groups, respectively. The RR was 0.976 (95% CI 0.878 to 1.084). Mean serum cholesterol levels decreased in all intervention groups and all but one control group. The reductions in mean serum cholesterol levels were significantly greater in the intervention groups; this did not result in significant differences in CHD or all-cause mortality.
Conclusions
The current available evidence found no significant difference in all-cause mortality or CHD mortality, resulting from the dietary fat interventions. RCT evidence currently available does not support the current dietary fat guidelines. The evidence per se lacks generalisability for population-wide guidelines.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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