Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry
Feliciano RP, Istas G, Heiss C, Rodriguez-Mateos A
Molecules (Basel, Switzerland) · 59 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Sin resultado de salud
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-08-25 · Molecules · vol. 21 · número 9 · pág. 1120
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 83 citas · más que el 96% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Biochemical Analysis and Sensing Techniques · Tea Polyphenols and Effects
- Palabras clave
- Hippuric acid, Urine, Chemistry, Polyphenol, Phenols, Urinary system, Excretion, Food science, Internal medicine, Medicine, Biochemistry, Antioxidant
- MeSH
- humans, fruit, double-blind method, eating, adolescent, adult, aged, middle aged, male, polyphenols, gastrointestinal microbiome, blueberry plants
4 autores
- Rodrigo Pedro Feliciano🇩🇪Heinrich Heine University Düsseldorf
- Geoffrey Istas🇩🇪Heinrich Heine University Düsseldorf
- Christian Heiß🇩🇪Heinrich Heine University Düsseldorf
- Ana Rodriguez‐Mateos🇩🇪 · autor de correspondenciaHeinrich Heine University Düsseldorf
Resumen
El texto original del estudio, en el idioma en que se publicó.
Recent studies have shown that blueberries may have cardiovascular and cognitive health benefits. In this work, we investigated the profile of plasma and urine (poly)phenol metabolites after acute and daily consumption of wild blueberries for 30 days in 18 healthy men. The inter-individual variability in plasma and urinary polyphenol levels was also investigated. Blood samples were collected at baseline and 2 h post-consumption on day 1 and day 30. Twenty-four-hour urine was also collected on both days. A total of 61 phenolic metabolites were quantified in plasma at baseline, of which 43 increased after acute or chronic consumption of blueberries over one month. Benzoic and catechol derivatives represented more than 80% of the changes in phenolic profile after 2 h consumption on day 1, whereas hippuric and benzoic derivatives were the major compounds that increased at 0 and 2 h on day 30, respectively. The total (poly)phenol urinary excretion remained unchanged after 30 days of wild blueberry intake. The inter-individual variability ranged between 40%-48% in plasma and 47%-54% in urine. Taken together, our results illustrate that blueberry (poly)phenols are absorbed and extensively metabolized by phase II enzymes and by the gut microbiota, leading to a whole array of metabolites that may be responsible for the beneficial effects observed after blueberry consumption.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.