Evaluation of low-level laser at auriculotherapy points to reduce postoperative pain in inferior third molar surgery: study protocol for a randomized controlled trial
Sampaio-Filho H, Sotto-Ramos J, Pinto EH, Cabral MR, Longo PL, Tortamano IP, Marcos RL, Silva DF, Pavani C, Horliana AC
Trials · 18 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de São Paulo (15/20535-1); Fundação de Amparo à Pesquisa do Estado de São Paulo (2015/); Fundação de Amparo à Pesquisa do Estado de São Paulo (20535-1)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-09-02 · Trials · vol. 17 · número 1 · pág. 432
- Editorial
- Springer Science+Business Media
- Citado
- 24 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Acupuncture Treatment Research Studies · Dental Anxiety and Anesthesia Techniques
- Palabras clave
- low-level laser therapy, auricular acupuncture, postoperative pain, third molar extraction, mandibular third molar, trismus, postoperative swelling, inflammatory cytokines, TNF-α, interleukins, non-pharmacological pain management, dysphagia, postoperative infection
- MeSH
- molar, third, humans, toothache, analgesics, non-narcotic, inflammation mediators, cytokines, pain measurement, treatment outcome, clinical protocols, tooth extraction, cross-over studies, double-blind method, research design, time factors, adolescent, adult, brazil, female, male, auriculotherapy, young adult, biomarkers, low-level light therapy, postoperative pain
10 autores
- Hélio Rodrigues Sampaio Filho🇧🇷Universidade Nove de Julho
- Juliane Sotto-Ramos🇧🇷Universidade Nove de Julho
- Erika Horácio Pinto🇧🇷Universidade Nove de Julho
- Márcia Regina Cabral🇧🇷Universidade Nove de Julho
- Priscila Larcher Longo🇧🇷Universidade Nove de Julho
- Isabel Peixoto Tortamano🇧🇷Universidade de São Paulo
- Rodrigo Labat Marcos🇧🇷Universidade Nove de Julho
- Daniela de Fátima Teixeira da Silva🇧🇷Universidade Nove de Julho
- Christiane Pavani🇧🇷Universidade Nove de Julho
- Anna Carolina Ratto Tempestini Horliana🇧🇷Universidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
A comfortable postoperative return to daily activities has increased the need to control inflammation after third molar surgery. Anti-inflammatory drugs and analgesics are not exempt from adverse effects such as allergies and chronic gastritis, and they are not without cost. The association between low-level laser and auricular acupuncture can be an alternative when conventional drugs are contraindicated. Among its advantages, we can mention the low risk of side effects, low cost and simplicity of application. The objective of this study is to evaluate the efficiency of low-level laser at auriculotherapy points in reducing postoperative pain in lower third molar surgery.
Methods/design
Ninety bilateral, symmetrical lower third molar surgeries will be performed in 45 healthy patients. Each patient will be their own control, through a split-mouth crossover study. One side of the mouth will be randomly chosen and, immediately after surgery, will be treated with low-level laser. After 21 days, the contralateral side will be operated on with low-level laser simulation used postoperatively. This regimen (laser application or not) will be repeated at 24 and 48 h after surgery. All patients will be requested to take analgesics (acetaminophen) if they have pain, i.e. in case of pain. Neither the surgeon nor the patients will know the assigned treatment. The primary variable will be postoperative pain assessed using a Visual Analog Scale, and the secondary variables will be trismus, edema, local temperature, dysphagia, presence of infection and painkiller ingestion. These variables will be assessed at baseline, 24 h, 48 h and 7 days after surgery. Blood samples for systemic inflammatory cytokine (TNF-α, IL-1, IL-6 and IL-8) analysis will be assessed at baseline and 24 h after surgery.
Discussion
Some authors believe that using a wavelength of 633 to 670 nm is a good option for laser therapy in the field of acupuncture. This wavelength can penetrate biological tissue to a depth of about 3 mm. However, for auriculotherapy points, the stimulus (mustard seeds, needles 1 to 2.5 mm) does not penetrate so deeply. For this reason, we chose a laser wavelength of 660 nm (red wavelength).
Trial registration
ClinicalTrials.gov Identifier: NCT02657174 , registered on 11 January 2016.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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