Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp
Hennis PJ, Mitchell K, Gilbert-Kawai E, Bountziouka V, Wade A, Feelisch M, Grocott MP, Martin DS
Nitric oxide : biology and chemistry · 18 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-09-09 · Nitric Oxide · vol. 60 · págs. 24–31
- Editorial
- Elsevier BV
- Citado
- 21 citas · más que el 87% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 26 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- High Altitude and Hypoxia · Exercise and Physiological Responses · Thermoregulation and physiological responses
- Palabras clave
- nitrate supplementation, beetroot juice, acute mountain sickness, high-altitude trekking, Mount Everest Base Camp, adolescents, blood pressure, heart rate, oxygen saturation, respiratory rate, exercise physiology, hypoxia adaptation, high-altitude adaptation, diastolic blood pressure, heart rate variability, peripheral oxygen saturation
- MeSH
- humans, beta vulgaris, altitude sickness, nitrates, blood pressure, heart rate, mountaineering, dietary supplements, adolescent, male, fruit and vegetable juices
8 autores
- Philip J Hennis🇬🇧 · autor de correspondenciaManchester Metropolitan University; UCL Biomedical Research Centre; University College London
- Kay Mitchell🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; NIHR Southampton Biomedical Research Centre; UCL Biomedical Research Centre; University College London
- Edward T. Gilbert-Kawai🇬🇧UCL Biomedical Research Centre; University College London
- Vassiliki P. Bountziouka🇬🇧University College London
- Angie Wade🇬🇧University College London
- Martin Feelisch🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; NIHR Southampton Biomedical Research Centre
- Michael P. W. Grocott🇬🇧University Hospital Southampton NHS Foundation Trust; NIHR Southampton Respiratory Biomedical Research Unit; NIHR Southampton Biomedical Research Centre; UCL Biomedical Research Centre; University College London
- Daniel Martín🇬🇧UCL Biomedical Research Centre; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to investigate the effects of dietary nitrate supplementation, in the form of beetroot juice, on acute mountain sickness (AMS) symptoms and physiological responses, in a group of young males trekking to Mount Everest Base Camp (EBC). Forty healthy male students (mean age (SD): 16 (1) yrs) trekked to EBC over 11 days. Following an overnight fast, each morning participants completed the Lake Louise AMS questionnaire and underwent a series of physiological tests: resting blood pressure as well as resting and exercising heart rate, respiratory rate, and peripheral oxygen saturation. The exercise test consisted of a standardised 2-min stepping protocol and measurements were taken in the last 10 s. Participants in the intervention arm of the study consumed 140 ml of concentrated beetroot juice daily, containing approximately 10 mmol of nitrate, while those in the control arm consumed 140 ml of concentrated blackcurrant cordial with negligible nitrate content. Drinks were taken for the first seven days at high altitude (days 2-8), in two equal doses; one with breakfast, and one with the evening meal. Mixed modelling revealed no significant between-groups difference in the incidence of AMS (Odds Ratio - nitrate vs.
Control
1.16 (95% CI: 0.59; 2.29)). Physiological changes occurring during ascent to high altitude generally were not significantly different between the two groups (Model Coef (95% CI) - average difference nitrate vs.
Control
systolic blood pressure, 0.16 (-4.47; 4.79); peripheral oxygen saturation, 0.28 (-0.85; 1.41); heart rate, -0.48 (-8.47; 7.50) (Model Coef (95% CI) - relative difference nitrate vs.
Control
ventilatory rate, 0.95 (0.82; 1.08)). Modelling revealed that diastolic blood pressure was 3.37 mmHg (0.24; 6.49) higher for participants in the beetroot juice, however this difference was no larger than that found at baseline and no interaction effect was observed. Supplementation with dietary nitrate did not significantly change symptoms of AMS or alter key physiological variables, in a group of adolescent males during a high altitude trekking expedition. There was no evidence of harm from dietary nitrate supplementation in this context. Given the wide confidence intervals in all models, a larger sample size would be required to exclude a false negative result. Our data suggest that prolonged oral nitrate supplementation is safe and feasible at altitude but has little physiological or clinical effect.
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