Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure trial
Harris WS, Masson S, Barlera S, Milani V, Pileggi S, Franzosi MG, Marchioli R, Tognoni G, Tavazzi L, Latini R, GISSI-HF Investigators
Nutrition research (New York, N.Y.) · 31 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-06-28 · Nutr Res · vol. 36 · número 9 · págs. 989–994
- Editorial
- Elsevier BV
- Citado
- 38 citas · más que el 96% de estudios similares · 6.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 index, red blood cell fatty acids, omega-3 acid ethyl esters, fish consumption, oleic acid, omega-3 fatty acids, GISSI-HF trial, heart failure, dietary fatty acid intake, cardiovascular risk factors
- MeSH
- erythrocytes, animals, fishes, humans, olea, esters, fatty acids, omega-3, oleic acid, diet, risk factors, feeding behavior, seafood, aged, middle aged, female, male, heart failure, hypolipidemic agents, olive oil
10 autores
- William Stephen Harris🇺🇸 · autor de correspondenciaUniversity of South Dakota
- Serge Masson🇮🇹Mario Negri Institute for Pharmacological Research
- Simona Barlera🇮🇹Mario Negri Institute for Pharmacological Research
- Valentina Milani🇮🇹Mario Negri Institute for Pharmacological Research
- Silvana Pileggi🇮🇹Mario Negri Institute for Pharmacological Research
- Maria Grazia Franzosi🇮🇹Mario Negri Institute for Pharmacological Research
- Roberto Marchioli🇬🇧IQVIA (United Kingdom)
- Gianni Tognoni🇮🇹Mario Negri Institute for Pharmacological Research
- Luigi Tavazzi🇮🇹Maria Cecilia Hospital
- Roberto Latini🇮🇹Mario Negri Institute for Pharmacological Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
The Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico-Heart Failure (GISSI-HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%. RBCs were collected from a subset of patients participating in the GISSI-HF study (n=461 out of 6975 randomized), at baseline and after 3 months of treatment with either an olive oil placebo or O3AEE (1 g/d). RBC FA levels were expressed as a percentage of total FA. Patients also reported their typical olive oil and fish intakes. RBC oleic acid levels were directly correlated with reported frequency of olive oil consumption, and the omega-3 index was correlated with reported fish intake (P for trends <0.001 for both). After treatment, the omega-3 index increased from 4.8±1.7% to 6.7±1.9% but was unchanged in the placebo group (4.7±1.7 to 4.8±1.5%) (P<.0001 for changes between groups). At 3 months, more patients reached the proposed target omega-3 index level of 8%-12% in the treated vs placebo group (22.6% vs. 1.3%, P<.0001), however, what omega-3 index levels were ultimately achieved after four years in this trial are unknown.
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