Effects of Omega-3 Fatty Acid in Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Lu W, Li S, Li J, Wang J, Zhang R, Zhou Y, Yin Q, Zheng Y, Wang F, Xia Y, Chen K, Liu T, Lu J, Zhou Y, Guo C, Guo C
Gastroenterology research and practice · 85 citas
Cómo se estudió
- Diseño
- Metaanálisis (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-01-01 · Gastroenterol Res Pract · vol. 2016 · págs. 1–11
- Editorial
- Hindawi Publishing Corporation
- Citado
- 132 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Liver Disease and Transplantation · Liver Diseases and Immunity
- Palabras clave
- Nonalcoholic fatty liver disease, Medicine, Internal medicine, Meta-analysis, Gastroenterology, Triglyceride, Polyunsaturated fatty acid, Randomized controlled trial, Fatty liver, Cholesterol, Fatty acid, Disease, Biochemistry, Biology
15 autores
- Wenxia Lu🇨🇳Tongji University; Shanghai Tenth People's Hospital; Nanjing Medical University
- Sainan Li🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Jingjing Li🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Jianrong Wang🇨🇳Tongji University; Shanghai Tenth People's Hospital; Nanjing Medical University
- Rong Zhang🇨🇳Tongji University; Shanghai Tenth People's Hospital; Nanjing Medical University
- Yuqing Zhou🇨🇳Tongji University; Soochow University; Shanghai Tenth People's Hospital; First Affiliated Hospital of Soochow University
- Qin Yin🇨🇳Tongji University; Soochow University; Shanghai Tenth People's Hospital; First Affiliated Hospital of Soochow University
- Yuanyuan Zheng🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Fan Wang🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Yujing Xia🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Kan Chen🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Tong Liu🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Jie Lu🇨🇳Tongji University; Shanghai Tenth People's Hospital
- Yingqun Zhou🇨🇳Tongji University; Soochow University; Shanghai Tenth People's Hospital; First Affiliated Hospital of Soochow University
- Chuanyong Guo🇨🇳 · autor de correspondenciaTongji University; Shanghai Tenth People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
A meta-analysis was conducted to assess the effect of omega-3 fatty acid supplementation (n-3 PUFAs) in lowering liver fat, liver enzyme (alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) levels), and blood lipids (triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL)) in patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). Methods. MEDLINE/PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL, Science Citation Index (ISI Web of Science), Chinese Biomedical Literature Database (CBM), and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant randomized controlled trials on the effects of n-3 polyunsaturated fatty acids (PUFAs) in patients with NAFLD from inception to May 2015. Ten studies were included in this meta-analysis. Results. 577 cases of NAFLD/NASH in ten randomized controlled trials (RCTs) were included. The results of the meta-analysis showed that benefit changes in liver fat favored PUFA treatment, and it was also beneficial for GGT, but it was not significant on ALT, AST, TC, and LDL. Conclusions. In this meta-analysis, omega-3 PUFAs improved liver fat, GGT, TG, and HDL in patients with NAFLD/NASH. Therefore, n-3 PUFAs may be a new treatment option for NAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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