Financiado en parte por AstraZeneca, GlaxoSmithKline, Sanofi, Biogen, Teva Pharmaceutical Industries, AFA Försäkring, Novo Nordisk
Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk
Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF
Neurology. Genetics · 156 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- U.S. Environmental Protection Agency
- Organización sin fines de lucro
- Robert Wood Johnson Foundation
- Organización sin fines de lucro
- National Multiple Sclerosis Society
- Organización sin fines de lucro
- American Heart Association
- Empresa
- AstraZeneca
- Empresa
- GlaxoSmithKline
- Empresa
- Sanofi
- Empresa
- Biogen
- Empresa
- Teva Pharmaceutical Industries
- Organización sin fines de lucro
- Rheumatology Research Foundation
- Universidad u hospital
- Harvard University
- Organización sin fines de lucro
- Association of Fraternity/Sorority Advisors Foundation
- Organización sin fines de lucro
- Multiple Sclerosis Society
- Universidad u hospital
- University of Oxford
- Empresa
- AFA Försäkring
- Universidad u hospital
- Karolinska Institutet
- Organización sin fines de lucro
- Knut och Alice Wallenbergs Stiftelse
- Empresa
- Novo Nordisk
- Gobierno
- Vetenskapsrådet
- Gobierno
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of California, San Francisco
- Gobierno
- Medical Research Council
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Mental Health
- Gobierno
- National Human Genome Research Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- National Institute of Neurological Disorders and Stroke
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- NINDS NIH HHS
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NHGRI NIH HHS
- Gobierno
- NIAID NIH HHS
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Human Genome Research Institute (T32 HG 000047); National Institute of Environmental Health Sciences (R01 ES017080); National Institute of Neurological Disorders and Stroke (F31NS093832); Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2015-00195); National Institute of Neurological Disorders and Stroke (F31NS096885); National Institute of Neurological Disorders and Stroke (R01NS049510); National Institute of Allergy and Infectious Diseases (R01AI076544)
Según 37 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-09-14 · Neurol Genet · vol. 2 · número 5 · pág. e97
- Editorial
- Wolters Kluwer
- Citado
- 212 citas · más que el 100% de estudios similares · 21.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Multiple Sclerosis Research Studies · Vitamin D Research Studies · Genetic Associations and Epidemiology
- Palabras clave
- multiple sclerosis, vitamin D, 25-hydroxyvitamin D, serum vitamin D levels, causal effects, disease susceptibility, age of onset, disease severity, HLA-DRB1*1501, polygenic risk score, single nucleotide polymorphisms
17 autores
- Brooke Rhead🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Maria Bäärnhielm🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Milena A. Gianfrancesco🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Amanda Mok🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Xiaorong Shao🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Hong Quach🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Ling Shen🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Catherine A. Schaefer🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Jenny Link🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Alexandra Gyllenberg🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Anna Karin Hedström🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Tomas P Olsson🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Jan A. Hillert🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Ingrid Skelton Kockum🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- M. Maria Glymour🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Lars S. Alfredsson🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
- Lisa F. Barcellos🇸🇪🇺🇸Karolinska University Hospital; Kaiser Permanente; University of California, San Francisco; Kaiser Permanente Oakland Medical Center; Region Stockholm; Karolinska Institutet; University of California, Berkeley
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality.
Methods
We conducted mendelian randomization (MR) analyses using an instrumental variable (IV) comprising 3 single nucleotide polymorphisms found to be associated with serum 25(OH)D levels at genome-wide significance. We analyzed the effect of the IV on MS risk and both age at onset and disease severity in 2 separate populations using logistic regression models that controlled for sex, year of birth, smoking, education, genetic ancestry, body mass index at age 18-20 years or in 20s, a weighted genetic risk score for 110 known MS-associated variants, and the presence of one or more HLA-DRB1*15:01 alleles.
Results
Findings from MR analyses using the IV showed increasing levels of 25(OH)D are associated with a decreased risk of MS in both populations. In white, non-Hispanic members of Kaiser Permanente Northern California (1,056 MS cases and 9,015 controls), the odds ratio (OR) was 0.79 (p = 0.04, 95% confidence interval (CI): 0.64-0.99). In members of a Swedish population from the Epidemiological Investigation of Multiple Sclerosis and Genes and Environment in Multiple Sclerosis MS case-control studies (6,335 cases and 5,762 controls), the OR was 0.86 (p = 0.03, 95% CI: 0.76-0.98). A meta-analysis of the 2 populations gave a combined OR of 0.85 (p = 0.003, 95% CI: 0.76-0.94). No association was observed for age at onset or disease severity.
Conclusions
These results provide strong evidence that low serum 25(OH)D concentration is a cause of MS, independent of established risk factors.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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