Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Women's Health Initiative Memory Study
Driscoll I, Shumaker SA, Snively BM, Margolis KL, Manson JE, Vitolins MZ, Rossom RC, Espeland MA
The journals of gerontology. Series A, Biological sciences and medical sciences · 33 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Health and Human Services
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Aging
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NIA NIH HHS
- Subvenciones
- U.S. Department of Health and Human Services (HHSN268201100002C); U.S. Department of Health and Human Services (HHSN2682011 00003C); National Institute on Aging (HHSN-271-2011-00004C,); U.S. Department of Health and Human Services (HHSN 268201100001C); U.S. Department of Health and Human Services (HHSN268201100046C); U.S. Department of Health and Human Services (HHSN268201100004C); U.S. Department of Health and Human Services (HHSN-271-2011-00004C)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2016-09-27 · J Gerontol A Biol Sci Med Sci · vol. 71 · número 12 · págs. 1596–1602
- Editorial
- Oxford University Press
- Citado
- 55 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dementia and Cognitive Impairment Research · Coffee research and impacts · Nutritional Studies and Diet
- Palabras clave
- caffeine consumption, dementia, cognitive impairment, older women, cognitive aging, dementia risk, Women's Health Initiative Memory Study, hormone therapy, sleep quality, depression
- MeSH
- humans, memory disorders, caffeine, estrogen replacement therapy, incidence, risk factors, cognition disorders, aged, united states, female, self report
8 autores
- Ira Frahmand Driscoll🇺🇸University of Wisconsin–Milwaukee
- Sally Ann Shumaker🇷🇺Department of Social Sciences
- Beverly M. Snively🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Karen L. Margolis🇺🇸HealthPartners
- JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University
- Mara Z. Vitolins🇺🇸Wake Forest University Health Sciences; Wake Forest University
- Rebecca C. Rossom🇺🇸HealthPartners
- Mark Andrew Espeland🇺🇸Wake Forest University Health Sciences; Wake Forest University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nonhuman studies suggest a protective effect of caffeine on cognition. Although human literature remains less consistent, reviews suggest a possible favorable relationship between caffeine consumption and cognitive impairment or dementia. We investigated the relationship between caffeine intake and incidence of cognitive impairment or probable dementia in women aged 65 and older from the Women's Health Initiative Memory Study.
Methods
All women with self-reported caffeine consumption at enrollment were included (N = 6,467). In 10 years or less of follow-up with annual assessments of cognitive function, 388 of these women received a diagnosis of probable dementia based on a 4-phase protocol that included central adjudication. We used proportional hazards regression to assess differences in the distributions of times until incidence of probable dementia or composite cognitive impairment among women grouped by baseline level of caffeine intake, adjusting for risk factors (hormone therapy, age, race, education, body mass index, sleep quality, depression, hypertension, prior cardiovascular disease, diabetes, smoking, and alcohol consumption).
Results
Women consuming above median levels (mean intake = 261mg) of caffeine intake for this group were less likely to develop incident dementia (hazard ratio = 0.74, 95% confidence interval [0.56, 0.99], p = .04) or any cognitive impairment (hazard ratio = 0.74, confidence interval [0.60, 0.91], p = .005) compared to those consuming below median amounts (mean intake = 64mg) of caffeine for this group.
Conclusion
Our findings suggest lower odds of probable dementia or cognitive impairment in older women whose caffeine consumption was above median for this group and are consistent with the existing literature showing an inverse association between caffeine intake and age-related cognitive impairment.
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