The effect of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for CVD risk reduction: a systematic review and meta-analysis of randomised-controlled trials
Ho HV, Sievenpiper JL, Zurbau A, Blanco Mejia S, Jovanovski E, Au-Yeung F, Jenkins AL, Vuksan V
The British journal of nutrition · 151 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
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- Marcadores de salud y funcionamiento
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Quién lo pagó
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Publicación
- Publicado
- 2016-10-11 · Br J Nutr · vol. 116 · número 8 · págs. 1369–1382
- Editorial
- Cambridge University Press
- Citado
- 244 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 81 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Lipoproteins and Cardiovascular Health · Natural Products and Biological Research
- Palabras clave
- oat β-glucan, LDL cholesterol, non-HDL cholesterol, apolipoprotein B, cardiovascular disease risk reduction, soluble dietary fiber, cholesterol-lowering effect, dietary intervention
- MeSH
- humans, seeds, cardiovascular diseases, hypercholesterolemia, cholesterol, beta-glucans, apolipoproteins b, anticholesteremic agents, risk, evidence-based medicine, solubility, dietary fiber, dietary supplements, middle aged, cholesterol, ldl, cholesterol, hdl, randomized controlled trials as topic, functional food, biomarkers, avena
8 autores
- Hoang V. T. Ho🇨🇦St. Michael's Hospital; University of Toronto
- John L. Sievenpiper🇨🇦St. Michael's Hospital; University of Toronto
- Andreea Zurbau🇨🇦St. Michael's Hospital; University of Toronto
- Sonia Blanco Mejía🇨🇦St. Michael's Hospital; University of Toronto
- Elena Jovanovski🇨🇦St. Michael's Hospital; University of Toronto
- Fei Au‐Yeung🇨🇦St. Michael's Hospital; University of Toronto
- Alexandra L. Jenkins🇨🇦St. Michael's Hospital
- Vladimir V.V. Vuksan🇨🇦 · autor de correspondenciaSt. Michael's Hospital; University of Toronto
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oats are a rich source of β-glucan, a viscous, soluble fibre recognised for its cholesterol-lowering properties, and are associated with reduced risk of CVD. Our objective was to conduct a systematic review and meta-analysis of randomised-controlled trials (RCT) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for the risk reduction of CVD. MEDLINE, Embase, CINAHL and Cochrane CENTRAL were searched. We included RCT of ≥3 weeks of follow-up, assessing the effect of diets enriched with oat β-glucan compared with controlled diets on LDL-cholesterol, non-HDL-cholesterol or apoB. Two independent reviewers extracted data and assessed study quality and risk of bias. Data were pooled using the generic inverse-variance method with random effects models and expressed as mean differences with 95 % CI. Heterogeneity was assessed by the Cochran's Q statistic and quantified by the I 2-statistic. In total, fifty-eight trials (n 3974) were included. A median dose of 3·5 g/d of oat β-glucan significantly lowered LDL-cholesterol (-0·19; 95 % CI -0·23, -0·14 mmol/l, P<0·00001), non-HDL-cholesterol (-0·20; 95 % CI -0·26, -0·15 mmol/l, P<0·00001) and apoB (-0·03; 95 % CI -0·05, -0·02 g/l, P<0·0001) compared with control interventions. There was evidence for considerable unexplained heterogeneity in the analysis of LDL-cholesterol (I 2=79 %) and non-HDL-cholesterol (I 2=99 %). Pooled analyses showed that oat β-glucan has a lowering effect on LDL-cholesterol, non-HDL-cholesterol and apoB. Inclusion of oat-containing foods may be a strategy for achieving targets in CVD reduction.
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