25-Hydroxyvitamin D and TSH as Risk Factors or Prognostic Markers in Thyroid Carcinoma
Danilovic DL, Ferraz-de-Souza B, Fabri AW, Santana NO, Kulcsar MA, Cernea CR, Marui S, Hoff AO
PloS one · 27 citas
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- CNPq (National Counsel of Technological and Scientific Development)
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (USP1676)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2016-10-13 · PLoS One · vol. 11 · número 10 · pág. e0164550
- Editorial
- Public Library of Science
- Citado
- 58 citas · más que el 96% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Thyroid Cancer Diagnosis and Treatment · Vitamin D Research Studies · Thyroid Disorders and Treatments
- Palabras clave
- Medicine, Thyroid cancer, Internal medicine, Thyroid carcinoma, Thyroid nodules, Thyroid, Odds ratio, Quartile, Cancer, Gastroenterology, Incidence (geometry), Oncology, Confidence interval
- MeSH
- humans, carcinoma, carcinoma, papillary, thyroid neoplasms, lymphatic metastasis, vitamin d deficiency, thyrotropin, vitamin d, prognosis, risk factors, retrospective studies, cross-sectional studies, adult, aged, middle aged, female, male, thyroid cancer, papillary
8 autores
- Debora Lúcia Seguro Danilovic🇧🇷 · autor de correspondenciaInstituto do Câncer do Estado de São Paulo; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Bruno Ferraz‐de‐Souza🇧🇷 · autor de correspondenciaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Amanda Wictky Fabri🇧🇷 · autor de correspondenciaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Nathalie Oliveira de Santana🇧🇷 · autor de correspondenciaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Marco Aurélio Vamondes Kulcsar🇧🇷 · autor de correspondenciaInstituto do Câncer do Estado de São Paulo
- Cláudio Roberto Cernea🇧🇷 · autor de correspondenciaInstituto do Câncer do Estado de São Paulo
- Suemi Marui🇧🇷 · autor de correspondenciaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Ana O. Hoff🇧🇷 · autor de correspondenciaInstituto do Câncer do Estado de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The increasing incidence of thyroid nodules demands identification of risk factors for malignant disease. Several studies suggested the association of higher TSH levels with cancer, but influence of 25-hydroxyvitamin D (25OHD) is controversial. This study aimed to identify the relationship of thyroid cancer with higher TSH levels and hypovitaminosis D and to evaluate their influence on prognostic characteristics of papillary thyroid carcinomas (PTC).
Methods
We retrospectively evaluated 433 patients submitted to thyroidectomy for thyroid nodules. Patients were categorized according to quartiles of TSH and 25OHD levels. Clinicopathological features were analyzed.
Results
Subjects with thyroid carcinomas were more frequently male and younger compared to those with benign disease. Their median TSH levels were higher and adjusted odds-ratio (OR) for cancer in the highest-quartile of TSH (> 2.4 mUI/mL) was 2.36 (1.36-4.09). Although vitamin D deficiency/insufficiency was prevalent in our cohort (84%), no significant differences in 25OHD levels or quartile distribution were observed between benign and malignant cases. Among 187 patients with PTC, analyses of prognostic features revealed increased risk of lymph nodes metastases for subjects with highest-quartile TSH levels (OR = 3.7, p = 0.029). Decreased 25OHD levels were not overtly associated with poor prognosis in PTC.
Conclusions
In this cross-sectional cohort, higher TSH levels increased the risk of cancer in thyroid nodules and influenced its prognosis, particularly favoring lymph nodes metastases. On the other hand, no association was found between 25OHD levels and thyroid carcinoma risk or prognosis, suggesting that serum 25OHD determination may not contribute to risk assessment workup of thyroid nodules.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.