The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort
Boyle VT, Thorstensen EB, Mourath D, Jones MB, McCowan LM, Kenny LC, Baker PN
The British journal of nutrition · 58 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Tertiary Education Commission
- Gobierno
- New Zealand Government
- Universidad u hospital
- University of Auckland
Según 3 financiadores declarados.
Publicación
- Publicado
- 2016-10-18 · Br J Nutr · vol. 116 · número 8 · págs. 1409–1415
- Editorial
- Cambridge University Press
- Citado
- 83 citas · más que el 98% de estudios similares · 9.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gestational Diabetes Research and Management · Pregnancy and preeclampsia studies · Vitamin D Research Studies
- Palabras clave
- Vitamin D and neurology, Pregnancy, Medicine, Obstetrics, vitamin D deficiency, Prospective cohort study, Gestation, Cohort study, Gestational diabetes, Small for gestational age, Eclampsia, Population, Cohort, Gestational age, Generation R, Pediatrics, Internal medicine, Environmental health
- MeSH
- humans, pregnancy complications, diabetes, gestational, fetal growth retardation, pre-eclampsia, premature birth, vitamin d deficiency, calcifediol, 25-hydroxyvitamin d 2, pregnancy outcome, severity of illness index, incidence, prevalence, risk, cohort studies, prospective studies, nutritional status, pregnancy, pregnancy trimester, second, new zealand, female, maternal nutritional physiological phenomena, biomarkers
7 autores
- Veronica T. Boyle🇳🇿 · autor de correspondenciaUniversity of Auckland
- Eric B. Thorstensen🇳🇿University of Auckland
- David Mourath🇸🇪Linköping University
- Beatrix Jones🇳🇿Massey University
- Lesley M. E. McCowan🇳🇿University of Auckland
- Louise C. Kenny🇮🇪University College Cork
- Philip Newton Baker🇬🇧🇳🇿University of Leicester; University of Auckland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations 75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.
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