Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women
Cunha AR, D'El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, Neves MF
Journal of hypertension · 50 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2016-10-19 · J Hypertens · vol. 35 · número 1 · págs. 89–97
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 77 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Cardiovascular Health and Disease Prevention
- Palabras clave
- Medicine, Pulse wave velocity, Blood pressure, Internal medicine, Thiazide, Arterial stiffness, Placebo, Magnesium, Intima-media thickness, Brachial artery, Hydrochlorothiazide, Hemodynamics, Ambulatory blood pressure, Endocrinology, Cardiology, Carotid arteries, Pathology
- MeSH
- humans, hypertension, magnesium, administration, oral, blood pressure, adult, aged, middle aged, female, carotid intima-media thickness, pulse wave analysis
7 autores
- Ana Rosa Cunha🇬🇧British Heart Foundation; University of Glasgow
- Jenifer d’El-Rei🇬🇧British Heart Foundation; University of Glasgow
- Fernanda Medeiros🇬🇧British Heart Foundation; University of Glasgow
- Bianca Umbelino🇬🇧British Heart Foundation; University of Glasgow
- Wille Oigman🇬🇧British Heart Foundation; University of Glasgow
- Rhian M. Touyz🇬🇧British Heart Foundation; University of Glasgow
- Mário Fritsch Neves🇬🇧🇧🇷 · autor de correspondenciaBritish Heart Foundation; Universidade do Estado do Rio de Janeiro; University of Glasgow
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia.
Method
We evaluated effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women in a randomized, double-blind, clinical trial. Hypertensive women (40-65 years) on hydrochlorothiazide and mean 24-h BP at least 130/80 mmHg were divided into placebo and supplementation (magnesium chelate 600 mg/day) groups. Patients were evaluated for nutritional and biochemical parameters, office and ambulatory blood pressure monitoring, brachial flow-mediated dilatation (FMD), peripheral arterial tonometry, assessment of carotid intima-media thickness, central hemodynamic parameters and pulse wave velocity at inclusion and after 6-month follow-up.
Results
The magnesium group had a significant reduction in SBP (144 ± 17 vs. 134 ± 14 mmHg, P = 0.036) and DBP (88 ± 9 vs. 81 ± 8 mmHg, P = 0.005) at 6 months, without effect on plasma glucose, lipids, or arterial stiffness parameters. The placebo group showed a significant increase in carotid intima-media thickness (0.78 ± 0.13 vs. 0.89 ± 0.14 mm, P = 0.033) without change in the magnesium group (0.79 ± 0.16 vs. 0.79 ± 0.19 mm, P = 0.716) after 6 months. The magnesium group demonstrated a significant increase in variation of FMD vs. the placebo group (+3.7 ± 2.1 vs. 2.4 ± 1.2%, P = 0.015). There was a significant correlation between the intracellular magnesium variation and FMD (r = 0.44, P = 0.011).
Conclusion
Magnesium supplementation was associated with better BP control, improved endothelial function and amelioration of subclinical atherosclerosis in these thiazide-treated hypertensive women.
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